Effect of high-sensitive C-reactive protein on vascular endothelial function in patients with essential hypertension

doi:10.3969/j.issn.1006-7795.2017.03.014

Abstract

Abstract: Objective To investigate the relationship between inflammation factor and endothelial function in essential hypertensive patients. Methods We continuedly enrolled 111 hypertensives from the Xuanwu Hospital Capital Medical University under the strict inclusion criteria. The Endo-PAT2000(Itamar Medical Inc.Caesarea) noninvasive testing equipment of vascular endothelial function measured reactive hyperemia index (RHI) which evaluate vascular endothelial function and arterial stiffness were operated in morning fasting adoption.Patients are divided into two groups:high high-sensitivity C-reactive protein(hs-CRP) group (hs-CRP>2.78,n=42),low hs-CRP group (hs-CRP ≤ 2.78,n=69). We also recorded age, blood pressure, history of smoking, fasting blood check hs-CRP. Results Systolic blood pressure and pulse pressure in high hs-CRP group were significantly higher than in low hs-CRP group.The pearson correlation analysis indicated that, RHI is negatively associated with hs-CRP(r=-0.247, P=0.010).Conclusion RHI gradually declined with the elevation of inflammation factor levels in hypertensives, and there is a linear correlation between them, which hinted that they may be associated with hypertensives endothelial injury. Further longitudinal studies are needed to better understand the causal relationship between endothelial function and inflammatory cytokines.

Key words: essential hypertension, high-sensitivity C-reactive protein(hs-CRP), reactive hyperemia index(RHI)

CLC Number:

R541.3

Zhou Yaqun, Ding Cuntao, Sun Xipeng, Li Jing, Zhu Weiwei, Hua Qi. Effect of high-sensitive C-reactive protein on vascular endothelial function in patients with essential hypertension[J]. Journal of Capital Medical University, 2017, 38(3): 397-400.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.03.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I3/397

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