Effects of glucose and lipid metabolism on vascular endothelial function in patients with essential hypertension

doi:10.3969/j.issn.1006-7795.2017.03.015

Abstract

Abstract: Objective To investigate the effects of glucose and lipid metabolism on endothelial function in patients with essential hypertension.Methods A total of 111 patients with essential hypertension were consecutively enrolled in this study from January 2016 to December 2016 in Xuanwu Hospital. All the patients were tested for biochemical indexes and vascular endothelial function tests to get blood glucose, blood lipid and reactive hyperemia index. According to the size of reactive hyperemia index (RHI) is divided into RHI normal group (n=63, RHI>1.67) and low RHI group (n=48, RHI<1.67). Application of correlation analysis and multiple linear regression to analyze the correlation between blood glucose and blood lipid and RHI in patients with essential hypertension. Results The levels of age, gender, smoking rate and other indicators were no statistical difference in the two groups (P>0.05). The levels of systolic blood pressure (SBP), glucose (GLU), glycosylated hemoglobin (HbA1c), low density lipoprotein-cholesterol (LDL-C) in low RHI group were significantly higher than those in normal RHI group (P<0.05). Pearson correlation analysis showed that RHI was negatively correlated with SBP, GLU, HbA1c and LDL-C (P<0.05). Multivariate linear regression analysis showed that RHI was negatively correlated with SBP, GLU and LDL-C. Conclusion Hyperglycemia and hyperlipidemia increase the vascular endothelial dysfunction in patients with essential hypertension.

Key words: essential hypertension, endothelial function, fasting blood glucose, lipoprotein

CLC Number:

R541.3

Ding Cuntao, Zhou Yaqun, Sun Xipeng, Li Jing, Zhu weiwei, Hua Qi. Effects of glucose and lipid metabolism on vascular endothelial function in patients with essential hypertension[J]. Journal of Capital Medical University, 2017, 38(3): 401-405.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.03.015

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I3/401

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