Correlation of Rock1 level with endothelial function and carotid intima-media thickness in elderly patients with unstable angina pectoris

doi:10.3969/j.issn.1006-7795.2021.06.030

Abstract

Abstract: Objective To study the relationship between the level of Rho-associated protein kinase 1 (ROCK1) in peripheral blood and vascular endothelial function and carotid intima-media thickness (IMT) in elderly patients with unstable angina pectoris (UA). Methods From June 2018 to June 2020, the elderly patients with suspected coronary heart disease in our hospital were selected and divided into UA group (with positive coronary angiography and diagnosis of UA) 74 cases and control group (with negative coronary angiography and no UA) 52 cases. Total cholesterol (TC), triglyceride (TG),high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol (LDL-C), uric acid, glycosylated hemoglobin (HbA1c) and other indicators were measured and compared in each group; Rock1 level in peripheral blood was detected by enzyme labeling method; flow mediated dilation(FMD) and IMT were measured and compared between the two groups. Pearson correlation was used to analyze the correlation between ROCK1 and parameters, and multiple linear regression was used to investigate the multiple factors. Results Except for smoking and HbA1c(P<0.05), there were no significant difference in gender, age, body mass index (BMI), diabetes, hypertension and blood lipid between the two groups (P>0.05). The level of FMD in UA group was lower than that in control group, while the level of IMT and ROCK1 in UA group was higher than that in control group (P<0.05). Multiple linear regression analysis showed that FMD (X4) and IMT (X5) were included in the regression equation, and ROCK1 (Y)=0.512X5-0.462X4+2.106. Conclusion There is a certain correlation between ROCK1 and endothelial function and IMT in elderly patients with UA.

Key words: Rho kinase, elderly, unstable angina pectoris, vascular endothelial function, carotid intima-media thickness

CLC Number:

R541.4

Fang Ye, Zou Lin, Li Xiao, Lin Jing, He Wei. Correlation of Rock1 level with endothelial function and carotid intima-media thickness in elderly patients with unstable angina pectoris[J]. Journal of Capital Medical University, 2021, 42(6): 1081-1085.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.06.030

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I6/1081

References

[1] 孙为鹏,史凤磊,朱淑珍,等. 大剂量阿托伐他汀对糖尿病合并不稳定型心绞痛患者经皮冠状动脉介入术后血脂及炎症的影响[J]. 中国临床保健杂志, 2020, 23(1): 84-88.
[2] Puelacher C,Gugala M,Adamson P D,et al. Incidence and outcomes of unstable angina compared with non-ST-elevation myocardial infarction[J]. Heart, 2019, 105(18): 1423-1431.
[3] 赵辉,陈辉,王志刚,等. 老年不稳定型心绞痛病人血浆组织蛋白酶S和血小板反应蛋白-1的水平及临床意义[J]. 中西医结合心脑血管病杂志, 2020, 18(6): 939-942.
[4] Wu J R,Liu S,Zhang X M,et al. Danshen injection as adjuvant treatment for unstable angina pectoris: a systematic review and meta-analysis[J]. Chin J Integr Med, 2017, 23(4): 306-311.
[5] Qazmooz H A,Smesam H N,Mousa R F,et al. Trace element, immune and opioid biomarkers of unstable angina, increased atherogenicity and insulin resistance: results of machine learning[J]. J Trace Elem Med Biol, 2021, 64: 126703.
[6] 李欣,赵玉玲,周树龙,等. 不稳定型心绞痛患者血清CTRP1水平变化及临床意义[J]. 重庆医学, 2019, 48(2): 259-262.
[7] Noma K,Rikitake Y,Oyama N,et al. ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury[J]. J Clin Invest, 2008, 118(5): 1632-1644.
[8] Abdel-Magid A F. Potential of ROCK inhibitors as treatment for cardiovascular diseases, cancer, and more[J]. ACS Med Chem Lett, 2019, 10(6): 841-842.
[9] 徐忠阳,王立启,徐振兴,等. RhoA／ROCK 信号通路与原发性高血压患者血压变异性及颈动脉内膜中层厚度的相关性[J]. 山东大学学报: 医学版, 2015, 53(2): 48-51.
[10] Ryliškytė L,Navickas R,Šerpytis P,et al. Association of aortic stiffness, carotid intima-media thickness and endothelial function with cardiovascular events in metabolic syndrome subjects[J]. Blood Press, 2019, 28(2): 131-138.
[11] 中国医师协会超声医师分会. 血管超声检查指南[J]. 中华超声影像学杂志, 2009, 18(10): 911-920.
[12] Puelacher C,Gugala M,Adamson P D,et al. Incidence and outcomes of unstable angina compared with non-ST-elevation myocardial infarction[J]. Heart, 2019, 105(18): 1423-1431.
[13] Liu Y C,Li Y,Zhang T P,et al. Analysis of biomarkers and metabolic pathways in patients with unstable angina based on ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry[J]. Mol Med Rep, 2020, 22(5): 3862-3872.
[14] Li X,Liu J J,Chen B,et al. A positive feedback loop of profilin-1 and RhoA/ROCK1 promotes endothelial dysfunction and oxidative stress[J]. Oxid Med Cell Longev, 2018, 2018: 4169575.
[15] 王本孝,王俊珺,王鹏,等. 2型糖尿病患者血清二肽基肽酶4水平与颈动脉粥样硬化的关系[J]. 中国神经免疫学和神经病学杂志, 2020, 27(4): 309-311, 325.
[16] Lin Y B,Dan H L,Lu J G. Overexpression of microRNA-136-3p alleviates myocardial injury in coronary artery disease via the Rho A/ROCK signaling pathway[J]. Kidney Blood Press Res, 2020, 45(3): 477-496.
[17] Shimokawa H. Reactive oxygen species in cardiovascular health and disease: special references to nitric oxide, hydrogen peroxide, and rho-kinase[J]. J Clin Biochem Nutr, 2020, 66(2): 83-91.
[18] 李立杰,葛华,陈曦,等. 麝香通心滴丸对高血压大鼠血管内皮功能及Rho/ROCK信号通路的影响[J]. 中国医科大学学报, 2020, 49(6): 485-489, 504.
[19] 陶欢,刘盛菲,凌敏. 基于Rho/ROCK信号通路的针刺对高脂血症模型大鼠血管内皮保护机制研究[J]. 中国中医基础医学杂志, 2019, 25(8): 1134-1136, 1142.
[20] 何姗姗,王留义,郭雷生,等. 不稳定型心绞痛患者血管内皮功能与同型半胱氨酸及颈动脉内膜中膜厚度相关[J]. 中国动脉硬化杂志, 2016, 24(7): 705-710.
[21] Yilmaz Avci A,Akkucuk M H,Torun E,et al. Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study[J]. Neurol Sci, 2019, 40(4): 703-711.