Correlation between serum vitamin D level and thyroid function and clinical characteristics in the newly-diagnosed type 2 diabetes mellitus patients

doi:10.3969/j.issn.1006-7795.2017.02.006

Abstract

Abstract: Objective To investigate the changes of serum thyroid hormone in elderly patients with type 2 diabetes mellitus (T2DM) and relevant factors. Methods According to the random number method,140 elderly patients with T2DM admitted into our hospital were assigned to the case group, and 147 healthy persons without diabetes in the same period were assigned to the control group. The thyroid-stimulating hormone(TSH),triiodothyronine(T3), thyronine (T4),anti-thyroid peroxidase antibody (TPOAb), anti-thyroglobulin antibody (TGAb) and thyroid-stimulating hormone receptor antibodies(TRAb) were assayed. Thyroid color Dopplar ultrasonography was performed. Fasting plasma glucose (FPG), glycosylated hemoglobin A1c (HbA1c) were additionally given for T2DM patients. The patients were divided into several groups according to their age、duration、FPG and HbA1c levels.The difference of thyroid hormone levels in each group and impact factors to thyroid hormones in T2DM patents were analyzed. Results ①Compared with control group, the level of T3 in the case group were significantly lower(P<0.05). ②With the increase of age、duration of diabetes、FPG and HbA1c level in the erlderly patients with diabetes,the level of T3 were significantly decreased(P<0.05).③In the case group, T3 was negatively correlated with age, duration of diabetes, FPG and HbA1c. Duration of diabetes and HbA1c were the independent factors influencing the changes of T3. Conclusion Thyroid hormones level in elderly patients with T2DM reflects the degree of glucose metabolism disorder.

Key words: elderly, diabetes, thyroid hormones

CLC Number:

R587.1

Ma Namin, Wang Min, Nie Yuanyuan, Yu Shilin, Geng Yahui, Dong Jianquan, Yuan Meiying, Yang Jinkui. Correlation between serum vitamin D level and thyroid function and clinical characteristics in the newly-diagnosed type 2 diabetes mellitus patients[J]. Journal of Capital Medical University, 2017, 38(2): 172-177.

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https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I2/172

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