Prepulse inhibition and the related factors among healthy people and patients with chronic schizophrenia

doi:10.3969/j.issn.1006-7795.2017.02.007

Abstract

Abstract: Objective To study the prepulse inhibition (PPI) and its related factors among healthy people and patients with chronic schizophrenia. Methods The PPI and cognitive performance (repeatable battery for the assessment of neuropsychological status (RBANS) and Stroop Color-world test) were tested in 50 healthy people (HP)and 75 chronic schizophrenia patients (SCZ). Positive and negative syndrome scale (PANSS) was used to evaluate the psychotic symptoms of patients. Results (1) Compared with HP, SCZ showed decreased PPI% (9.4%±29.3% vs 31.7%±26.2%,P<0.001), and the difference between two groups was found in cognitive performance (RBANS scores and its scores of all items in RBANS, Stroop color and word time). (2) Related factors of PPI% in healthy people:univariate analysis in PPI% showed that gender (male vs female, P<0.05), smoking (r=0.29,P<0.05), RBANS scores (r=0.30,P<0.05) and attention item scores (r=0.29,P<0.05) on the impact of the PPI% were statistically significant. Furthermore, multivariate ridge regression showed the same results as well as univariate analysis (ridge parameter k=2.95, adjusted R²=0.33, P<0.05). (3) Related factors of PPI% in people with chronic schizophrenia:PPI% was significantly correlated with smoking (r=0.23,P<0.05), relapses (>3 times vs≤3 times, P<0.05) in univariate analysis. And mutlivariate ridge regression showed the significantly related factors of PPI% in schizophrenia patients were gender, smoking and relapses (ridge parameter k=2.58, adjusted R²=0.26, P<0.05). Conclusion PPI% is an indicator of sensory gating, and its related factors may be different for different groups. Female and smoking may be protective factors for sensory gating in schizophrenia, more recurrence may be destroy the sensory gating function of patients with schizophrenia.

Key words: schizophrenia, prepulse inhibition, cognitive function, ridge regression

CLC Number:

R749.3

Fan Yu, Yang Ningbo, Tian Qing, Zhu Xiuqiang, Wang Chuanyue. Prepulse inhibition and the related factors among healthy people and patients with chronic schizophrenia[J]. Journal of Capital Medical University, 2017, 38(2): 178-185.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.02.007

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I2/178

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