Diffusion kurtosis imaging study: the effects of ApoEε4 epsilon4 alleles on brain microstructure in healthy elders

doi:10.3969/j.issn.1006-7795.2017.02.027

Abstract

Abstract: Objective To compare the difference of the brain microstructure between apolipoprotein Eε4 (ApoEε4) allele carriers and noncarriers of normal elderly people with normal cognitive state and to explore the influence of ApoEε4 alleles on its brain microstructure by using diffusion kurtosis imaging (DKI) magnetic resonance technology. Methods The ApoEε4 alleles was detected in oral mucosa of 18 normal elders; All subjects underwent routine magnetic resonance imaging(MRI) scanning and DKI scanning. Mean kurtosis(MK) and fractional anisotraphy(FA) values were measured in bilateral frontal lobe, parietal lobe, temporal lobe, posterior cingulate cortex, splenium of corpus callosum and hippocampe. The two-sample t-test was used to compare the parameters between the ApoEε4 allele carriers and noncarriers. Results MK value in the temporal lobe and hippocampus of the ApoEε4 allele carriers was significantly lower than in that of noncarriers (P<0.05). FA value in the hippocampus of the ApoEε4 allele carriers was significantly lower than in that of noncarriers (P<0.05). Conclusion Microstructural changes of the brain of ApoEε4 alleles carriers in normal elderly persons with normal cognitive state are more obvious. DKI could detect the influence of ApoEε4 allele on the microstructural changes of the brain in the eraly time.

Key words: normal elderlys, diffusion kurtosis imaging, ApoEε4 alleles

CLC Number:

R445.2

Zhao Yanling, Wang Jun, Wang Xiaochun, Zhang Hui, Hao Xiaoyong, Li Dan. Diffusion kurtosis imaging study: the effects of ApoEε4 epsilon4 alleles on brain microstructure in healthy elders[J]. Journal of Capital Medical University, 2017, 38(2): 304-307.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.02.027

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I2/304

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