Clinical study on circulating VCAM-1 to evaluate the metastasis risk of mastoscopic axillary lymph node dissection

doi:10.3969/j.issn.1006-7795.2017.02.028

Abstract

Abstract: Objective To elucidate the change after mastoscopic axillary lymph node dissection (MALND) and conventional axillary lymph node dissection (CALND) and further prove the safety of MALND.Methods 104 breast cancer patients (January 1st, 2014 to July 31 st, 2015) from Breast Minimally Invasive Center, Fuxing Hospital,Capital Medical University who were undergone ALND were randomly divided into two groups:CALND(n=52) and MALND(n=52). The peripheral blood samples were respectively collected in pre-operation and 1,3,5 days after operation. The circulating levels of vascular cell adhesion molecular-1 (VCAM-1) in blood were analyzed by ELISA. Results Circulating VCAM-1 levels of CALND group on postoperative 1 d(51.74±1.37)ng/mL,3 d(52.64±1.24)ng/mL,5 d(52.22±1.29)ng/mL decreased significantly than that of pre-operation (56.56±1.24)ng/mL. And the figures of MALND group turn to be(53.24±1.21)ng/mL,(52.07±1.34)ng/mL,(48.99±1.27)ng/mL,(58.66±0.95) ng/mL. The VCAM-1 levels of MALND group is lower than that of CALND, but there was no statistical difference between the two groups (P>0.05). Conclusion The change of circulating VCAM-1of patients after MALND is same to that of CALND. There is no evidence that MALND increases the risk of blood dissemination of tumor.

Key words: breast cancer, mastoscopic axillary lymph node dissection(MALND), vascular cell adhesion molecular-1 (VCAM-1)

CLC Number:

Luo Chengyu, Fan Kemin, Ge Shasha, Cui Zhimiao. Clinical study on circulating VCAM-1 to evaluate the metastasis risk of mastoscopic axillary lymph node dissection[J]. Journal of Capital Medical University, 2017, 38(2): 308-312.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.02.028

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I2/308

References

[1] 曹华祥,周士福,许示心,等.VCAM-1表达与乳腺癌血管生成及临床病理的关系[J].江苏医药,2003,29(7):491-493.
[2] 吴勇, 刘弋. 结直肠癌中 ICAM-1和 VCAM-1的表达和临床意义[J].安徽医科大学学报, 2015,50(8):491-493.1124-1127.
[3] 郭美琴,姜军,杨新华,等.吸脂法腔镜腋窝淋巴结清除术野脱落细胞学研究[J].中华肿瘤防治杂志,2009,16(9):710-712.
[4] 李同义,于志勇,门秀东,等.基于脂肪溶解抽吸的腔镜腋窝淋巴结清扫术治疗乳腺癌疗效观察[J].山东医药,2013,53(13):79-80.
[5] 任洪伟.乳腔镜腋窝淋巴结清扫术的临床效果及预后分析[J].河北医药,2015,37(16):2466-2468.
[6] Luo C, Guo W, Yang J, et al. Comparison of mastoscopic and conventional axillary lymph node dissection in breast cancer: Long-term results from a randomized, multicenter trial [J].Mayo Clin Proc, 2012, 87(12):1153-1161.
[7] Ding B, Qian L, Zhao Y, et al.Meta-analysis of endoscopic axillary lymph node dissection versus conventional open excision forbreast cancer[J].Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2015,40(7):782-789.
[8] 李果生,李文茂,李方明,等.乳腔镜腋窝淋巴结清扫与常规手术的对比[J].中国普通外科杂志,2013,22(11):1517-1519.
[9] 李同义,于志勇,门秀东,等.基于脂肪溶解抽吸的腔镜腋窝淋巴结清扫术治疗乳腺癌疗效观察[J].山东医药,2013,53(13):79-80.
[10] 郭美琴,姜军,范林军,等.腔镜腋窝淋巴结清扫术与传统腋窝清扫术前后外周血潜伏肿瘤细胞的对比研究[J].中华乳腺病杂志(电子版),2007,1(3):36-39.
[11] 姜军.乳腺癌腔镜腋窝淋巴结清扫术的争论与实践[J]. 中华普通外科学文献,2009,3(6):456-457.
[12] Luo C Y, Zhang J, Ji X X, et al. Experience of a large series of mastoscopic axillary lymph node dissection [J]. J Surg Oncol,2008,98(2):89-93.
[13] 骆成玉.理念与技术并重,促进乳腺微创与功能诊治发展[J]. 中国普外基础与临床杂志,2012,19(9):923-925.
[14] Owaki T, Kijima Y, Yoshinaka H,et al. Present status of endoscopic mastectomy for breast cancer[J].World J Clin Oncol, 2015,6(3):25-29.
[15] 丁永斌. VCAM-1的表达与乳癌血管生成、生长、转移的关系研究[J]. 中国实用外科杂志, 2002, 22(2):110-111.
[16] 严群,张鹏,邹传胜,等.血管黏附因子-1在乳腺癌中的表达及其与乳腺癌转移的关系[J]. 同济医科大学学报,2001,30(4):342-343.
[17] Huang X, He D, Ming J, et al.High-density lipoprotein of patients with breast cancer complicated with type 2 diabetes mellitus promotes cancer cells adhesion to vascular endothelium via ICAM-1 and VCAM-1 upregulation[J].Breast Cancer Res Treat, 2016,155(3):441-455.
[18] 钱剑, 陈瑶, 齐乐龙. 组织内及外周血细胞间黏附分子-1与血管细胞间黏附分子-1在胰腺癌病人中的变化研究[J]. 中国生化药物杂志, 2015,35(6):80-82.
[19] 骆成玉,季晓昕,林华,等.乳腔镜和常规腋窝淋巴结清扫淋巴结病理改变的随机对照研究[J]. 首都医科大学学报,2012,33(1):63-67.