Brain 1H-MRS imaging characteristics in patients with overactive bladder and its correlation with clinical symptoms

doi:10.3969/j.issn.1006-7795.2017.06.014

Abstract

Abstract: Objective To measure the metabolic changes of the brain using the proton magnetic resonance spectroscopy (¹H-MRS) in the patients with overactive bladder (OAB).Methods We recruited 23 patients with OAB and 23 healthy controls respectively. All participants were evaluated with Self-Rating Depression Scale (SDS) and 23 patients were evaluated with Overactive Bladder Symptom Score (OABSS). Multi-voxel ¹H-MRS was performed with a volume of interest located in the centrum semiovale which contains both frontal lobe and cingulate gyrus. Two main ratios of N-acetyl aspartate (NAA)/creatine (Cr) and choline (Cho)/Cr were obtained. The ratios in both frontal lobe and cingulategyrus between the two groups were compared. And the correlation between NAA/Cr, Cho/Cr and SDS, OABSS scores were analyzed. Results We found significantly lower levels of NAA/Cr ratios in both anterior frontal cortex, right medial frontal cortex, both anterior cingulate cortex and left posterior cingulate cortex in patients with OAB than in healthy controls (P<0.05). NAA/Cr in right medial frontal cortex was negatively correlated with SDS scores (r=-0.361,P<0.05).Conclusion The primary finding of the study is significant reduction in the ratios of NAA/Cr in both anterior frontal cortex, right medial frontal cortex, both anterior cingulate cortex and left posterior cingulate cortex in OAB patients, which indicates a marker of neuronal loss or dysfunction in patients with OAB.

Key words: overactive bladder, magnetic resonance spectroscopy, brain

CLC Number:

R445.2

Zhou Yang, Wang Shuangkun, Zuo Long, Wang Biao, Gu Hua. Brain ¹H-MRS imaging characteristics in patients with overactive bladder and its correlation with clinical symptoms[J]. Journal of Capital Medical University, 2017, 38(6): 846-850.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.06.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I6/846

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Brain ¹H-MRS imaging characteristics in patients with overactive bladder and its correlation with clinical symptoms

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