Abstract: Objective Research the brain function and the heart rate variability of insomnia patients with anxiety, analyzing their autonomic neural function and the features on brain using, which is anticipated to improve the vagal function and reduce the consumption of brain energy, and thus, slower the heart rate, relieve anxiety and insomnia symptoms, as well as to improve the clinical efficacy. Methods Take 443 patients with insomnia as a sample who were admitted to Dongzhimen Hospital of Beijing University of Chinese Medicine from October 2016 to August 2018, record their general information, Pittsburgh Sleep Quality Index (PSQI) scores, heart rate rariability (HRV) index and brain function. Divide the patients to 2 groups according to PSQI scores,of which ＜7 are 43 patients as non-anxiety group, while those ≥14 are 269 cases with anxiety, from which randomly select 43 of 269 by the ratio of 1∶1 age stratification. The selected 43 non-anxiety patients is regarded as the case group, while the 43 anxiety as the control. A comparison between the two groups proceeds. Results The anxiety group has more women(P<0.05); gets worse in the sleep quality(P<0.05); in personality, has more cases of those who are overburdened, overstrung and scrupulous(P<0.05), brain load, brain fatigue and attention-awaken increased (P<0.05), among HAV index, total power (TP) reduces, low frequency power (LF) and LF/high frequency power (HF) rises (P<0.05). Conclusion Patients with anxiety have worse situation of insomnia; the anxieties' HRV decreases accompanied by an increase in sympathetic activity; the continuous use of brain result in fatigue and tension of brain and an increasing brain energy consumption as well.

Key words: insomnia, anxiety, heart rate variability, brain function