Effects of different doses of dexmedetomidine on postoperative agitation in children receiving craniotomy

doi:10.3969/j.issn.1006-7795.2021.03.020

Abstract

Abstract: Objective To investigate the effect of different doses of dexmedetomidine (DEX) on postoperative agitation in children receiving craniotomy. Methods Total 120 children aged 3-14 years old receiving elective craniotomy were enrolled and divided into four groups according to the dosage of dexmedetomidine: low-dose group(0.4 μg·kg^-1·h^-1), medium dose group(0.6 μg·kg^-1·h^-1), high-dose group(0.8 μg·kg^-1·h^-1) and normal saline control group, with 30 cases in each group. Primary outcome indexes were based on the incidence of agitation after the craniotomy. Secondary outcomes indexes were based on recovery time and the incidence of choking. Results The incidences of agitation in the middle dose group and the high dose group were significantly lower (17%, 11% vs 64%, P<0.01). The incidences of choking during extubation were reduced in a dose-dependent manner (P<0.01). The recovery time after drug withdrawal was significantly longer in the high-dose group (P<0.01). Conclusion Infusion of dexmedetomidine at the concentration of 0.6 μg·kg^-1·h^-1 at the end of operation significantly reduces the incidence of agitation and choking after craniotomy in children, and the degree of sedation was more appropriate.

Key words: dexmedetomidine, children, craniotomy, recovery period, agitation

CLC Number:

R614

Ma Jiajia, Yue Hongli, Wang Dexiang, Jin Xu, Han Ruquan. Effects of different doses of dexmedetomidine on postoperative agitation in children receiving craniotomy[J]. Journal of Capital Medical University, 2021, 42(3): 459-463.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.03.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I3/459

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