Abstract: Objective To analyze the clinical characteristics of invasive salmonellosis for better clinical diagnosis and management. Methods A retrospective investigation of the clinical manifestation, laboratory test, clinical course and outcome,antimicrobial susceptibility of Salmonella clinical isolates of 23 cases with invasive Salmonellosis were tested between March 2010 and October 2016 in Beijing Chaoyang Hospital. Results Among the 23 invasive cases in this paper,17 patients were male patients,the median age was 62 years;Most of them(78.26%) had the basic disease/conditions. The median age of 12 cases with local infection(including 4 cases of infectious aneurysms)was 67.5 years, and 91.67% had underlying diseases. Most patients presented with high fever(86.96%)and chill (91.3%),the intestinal symptom like diarrhea was infrequent(30.43%).The median count of blood leukocytes was 9.22(2.53,26.33)×10⁹/L,13 cases (56.5%) of white blood cells (WBC)<10×10⁹/L, and eosinophil% less than 0.5% were 78.26%.Nineteen cases were cured or improved, 2 cases transferred to other hospitals,and 2 cases died. The sensitivity of Salmonella to ciprofloxacin and ampicillin were lower (37.5%, 34.78%respectively)(P<0.05).Intermediate to ciprofloxacin accounted for 56.25%.Conclusion The incidence of invasive salmonellosis was associated with advanced age and presence of underlying diseases,which can take the form of a variety of diseases. It was characterized by high fever, chills, rare diarrhea. In the half of the cases, whole blood leukocytes did not increase and acidophilic granulocyte reduced. Clinicians should keep in mind that infected aortic aneurysm is highly possible in patients with atherosclerosis when blood bacteria cultivation result of Salmonella. Antibiotics are chosen to avoid ampicillin and ciprofloxacin, which can be considered for three-generation cephalospore and levofloxacin.

Key words: Salmonella, invasive salmonellosis, infectious aneurysm, ciprofloxacin