Correlation between the brain and age-dependent α-synuclein phosphorylation and oligomerization in the gut of cynomolgus monkeys

doi:10.3969/j.issn.1006-7795.2017.06.019

Journal of Capital Medical University ›› 2017, Vol. 38 ›› Issue (6): 874-878.doi: 10.3969/j.issn.1006-7795.2017.06.019

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Correlation between the brain and age-dependent α-synuclein phosphorylation and oligomerization in the gut of cynomolgus monkeys

Yang Weiwei^1,2,3,4, Li Xin^1,2,3,4, Li Xuran^1,2, Yu Shun^1,2,3,4

1. Department of Neurobiology, Xuanwu Hospital, Capital Medical University, Beijing Institute of Geriatrics, Beijing 100053, China;
2. Clinical Center for Parkinson's Disease, Capital Medical University, Beijing 100053, China;
3. Beijing Key Laboratory for Parkinson's Disease and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China;
4. National Clinical Research Center for Geriatric Disorders, Beijing 100053, China

Received:2017-10-23 Online:2017-11-21 Published:2017-12-16
Supported by:
This study was supported by National Natural Science Foundation of China (81371200, 81071014, 81401042), Beijing Municipal Administration of Hospitals' Mission Plan (SML20150803), Beijing Municipal Science & Technology Commission (Z161100005116011,Z171100000117013), Beijing Municipal Commission of Health and Family Planning (PXM2017_026283_000002).

Abstract

Abstract: Objective To explore age-dependent alterations in oligomeric and phosphorylated α-synuclein(o-α-Syn and p-α-Syn) in the colon and brain, analyze the correlation for levels of o-α-Syn and p-α-Syn between the colon and different regions of the brain.Methods ELISA methods specific for o-α-Syn and p-α-Syn were used to measure the levels of o-α-Syn and p-α-Syn in the colon and brain of different ages of cynomolgus monkeys. Results Levels of o-α-Syn and p-α-Syn increased significantly with age in the colon and brain, statistically significant difference was observed between the old monkeys and the young and middle-aged monkeys (P< 0.01). Levels of o-α-Syn and p-α-Syn in the colon were positively correlated with those in the temporal lobe, hippocampus, striatum and thalamus of the brain.Conclusion Levels of o-α-Syn and p-α-Syn increase with age in the colon and brain and positively correlated between the colon and some vulnerable brain regions.

Key words: α-synuclein, colon, brain, cynomolgus monkeys, aging

CLC Number:

R338

Yang Weiwei, Li Xin, Li Xuran, Yu Shun. Correlation between the brain and age-dependent α-synuclein phosphorylation and oligomerization in the gut of cynomolgus monkeys[J]. Journal of Capital Medical University, 2017, 38(6): 874-878.

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Correlation between the brain and age-dependent α-synuclein phosphorylation and oligomerization in the gut of cynomolgus monkeys

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