Effects of cornel iridoid glycoside on the behavioral and pathological changes on senescence-accelerated mouse prone 8

doi:10.3969/j.issn.1006-7795.2021.05.010

Abstract

Abstract: Objective To investigate the effects of cornel iridoid glycoside (CIG) on cognitive behavioral and Alzheimer's-like pathological changes in senescence-accelerated mouse prone 8 (SAMP8) mice. Methods The drug of CIG was chronically administered with intragastric injection to 8-month-old SAMP8 mice and senescence accelerated mouse/resistant 1 (SAMR1) mice in the control for two months. The locomotor activity was tested by the locomotor activity system. The passive avoidance memory function was measured by step through test. The Western blotting was used to detect the expression of amyloid precursor protein amyloid precursor protein (APP) and synapse associated protein. Results The results showed that SAMP8 mice exhibited impaired locomotor activity and cognition. Intragastric administration of CIG for 2 months obviously improved the locomotor activity and cognitive function of SAMP8 mice. CIG treatment elevated the levels of soluble APPα fragment, a disintegrin and metalloproteinase 10 (ADAM10) and insulin-degrading enzyme (IDE). Moreover, CIG increased the expression of synaptophysin, postsynaptic density protein 95, AMPA receptor subunit 1 and phosphorylation of calmodulin dependent protein kinase IIα (CaMKIIα). Conclusion CIG may be beneficial to treating the aging induced cognitive impairment and Alzheimer's-like pathological changes.

Key words: cornel iridoid glycoside, aging, Alzheimer's disease, SAMP8 mice, amyloid precursor protein, synapse

CLC Number:

R745.1

Ma Denglei, Li Yanzheng, Zhu Yanqiu, Li Lin, Zhang Lan. Effects of cornel iridoid glycoside on the behavioral and pathological changes on senescence-accelerated mouse prone 8[J]. Journal of Capital Medical University, 2021, 42(5): 754-760.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.05.010

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I5/754

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