Study of fractional exhaled nitric oxide value in healthy subjects of Beijing-Tianjin-Hebei Region

doi:10.3969/j.issn.1006-7795.2018.01.011

Abstract

Abstract: Objective To establish measuring fractional exhaled nitric oxide (FeNO) provides an indication of airway inflammation and is used as an inflammatory marker for airway inflammation management. However, reference values and determinants of FeNO levels are not well defined in local healthy adults reference values in nonsmoking, healthy adults and to determine the factors related to FeNO levels in Beijing-Tianjin-Hebei regions.Methods This randomized multi-center study was carried on in twenty medical centers; 523 nonsmoking, healthy adults (male 221, female 302) were involved in the same period. FeNO was measured in healthy adults according to American Thoracic Society Guidelines (single breath online, exhalation flow 50 mL/s) with NIOX exhaled nitric oxide monitoring system (NIOX, Aerocrine AB, Sweden), and the correlation between related factors[such as:age, height, weight, body mass index (BMI), region and lung function] and FeNO level were investigated. Lung function was measured using spirometry, and atopic status was excluded based on the skin-prick test.Results FeNO normal values in healthy adults are similar compared with previous reports. The geometric mean of FeNO in 523 healthy adult was 16×10^-6, and 95% confidence interval (skewed distribution) was (5-26)×10^-6. FeNO correlated significantly with age, gender and regional distribution (P<0.05). However, weight, height, and BMI did not produce a significant impact on adult FeNO value (P>0.05). The normal ranges of FeNO were (5-26)×10^-6 in healthy adults of our study.Conclusion The result of this study suggests that 26×10^-6 seems to be the reference FeNO value in healthy adults in Beijing-Tianjin-Hebei regions. We believe that the presented FeNO reference values and the determining factors could be useful for research and clinical practice in the adult population of Beijing-Tianjin-Hebei regions. However, influencing factors such as age, gender and region must be considered.

Key words: fractional exhaled nitric oxide (FeNO), adult, gender, region, reference value

CLC Number:

R856.74

Liu Chengyao, Wang Xiangdong, Liu Zhongyan, Zhang Luo. Study of fractional exhaled nitric oxide value in healthy subjects of Beijing-Tianjin-Hebei Region[J]. Journal of Capital Medical University, 2018, 39(1): 57-62.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.01.011

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I1/57

References

[1] Rodway G W, Choi J, Hoffman L A, et al. Exhaled nitric oxide in the diagnosis and management of asthma:clinical implications[J]. Chron Respir Dis, 2009, 6(1):19-29.
[2] Profita M, La Grutta S, Carpagnano E,et al. Noninvasive methods for the detection of upper and lower airway inflammation in atopic children[J]. J Allergy Clin Immunol, 2006,118(5):1068-1074.
[3] Liu C, Zheng M, He F,et al. Role of exhaled nasal nitric oxide in distinguishing between chronic rhinosinusitis with and without nasal polyps[J]. Am J Rhinol Allergy,2017,31(6):389-394.
[4] Bacharier L B, Boner A, Carlsen K H, et al. Diagnosis and treatment of asthma in childhood:a PRACTALL consensus report[J]. Allergy, 2008, 63(1):5-34.
[5] American Thoracic Society. An official ATS clinical practice guideline:Interpretation of exhaled nitric oxide levels (FeNO) for clinical applications[J]. Am J Respir Crit Care Med, 2011, 184(5):602-615.
[6] Taylor D R, Pijnenburg M W, Smith A D, et al. Exhaled nitric oxide measurements:clinical application and interpretation[J].Thorax, 2006, 61(9):817-827.
[7] American Thoracic Society and European Respiratory Society. ATS/ERS Recommendation for standardized procedures for the online and offline measurement of exhaled lower resiratory nitric oxide and nasal nitric oxide, 2005[J]. Am J Respir Crit Care Med, 2005,171(8):912-930.
[8] Buchvald F, Baraldi E, Carraro S, et al. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years[J].J Allergy Clin Immunol, 2005, 115(6):1130-1136.
[9] Franklin P J, Turner S W, Le Souëf P N, et al. Exhaled nitric oxide and asthma:complex interactions between atopy, airway responsiveness, and symptoms in a community population of children[J].Thorax, 2003, 58(12):1048-1052.
[10] Avital A, Uwyyed K, Berkman N, et al. Exhaled nitric oxide is age-dependent in asthma[J].Pediatr Pulmonol, 2003, 36(5):433-438.
[11] Olin A C, Rosengren A, Thelle D S, et al.Height, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sample[J].Chest, 2006, 130(5):1319-1325.
[12] Struben V M, Wieringa M H, Mantingh C J, et al. Nasal NO:normal values in children age 6 through to 17 years[J]. Eur Respir J, 2005, 26(3):453-457.
[13] 张罗,罗雪瑞,刘承耀,等.健康成人口鼻呼出气一氧化氮含量测定机器影响因素分析[J].中华耳鼻咽喉头颈外科杂志,2009, 44(4):302-306.
[14] 夏玉红,王志新,陈宏民.呼出气一氧化氮在慢性咳嗽病因诊断及预测激素敏感性中的应用价值[J].中国煤炭工业医学杂志,2015,18(3):429-431.
[15] Dressel H, de la Motte D, Reichert J, et al. Exhaled nitric oxide:independent effects of atopy, smoking, respiratory tract infection, gender and height[J].Respir Med, 2008,102(7):962-969.
[16] Kim S H, Kim T H, Sohn J W,et al.Reference values and determinants of exhaled nitric oxide in healthy Korean adults[J]. J Asthma, 2010, 47(5):563-567.