Angiotensin Ⅱ type 1 receptor autoantibody-positive female rats showed hypertensive disorder after pregnancy

doi:10.3969/j.issn.1006-7795.2019.02.019

Abstract

Abstract: Objective To investigate whether angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA)-positive rats exhibited the phenomenon of gestational hypertension after pregnancy. Methods Clinical serum samples were collected to detect the presence of AT1-AA in non-pregnant healthy women by enzyme linked immunosorbent assay (ELISA). AT1-AA-positive rat model was established by active immunization. Tail-cuff method was used to measure the systolic blood pressure and the mesenteric artery ring was used to detect vascular function. Results AT1-AA was also present in some healthy women who were not pregnant. There was no significant difference in blood pressure between AT1-AA-positive rats and control rats before pregnancy, but the systolic pressure of AT1-AA-positive rats after pregnancy was significantly higher than that of control rats. Mesenteric artery ring showed that the vasoconstriction was increased (vehicle group:110%±5%, immunized group:130%±10%, P<0.05), and endothelium-dependent/non-endothelium-dependent vasodilation was decreased in AT1-AA-positive rats after pregnancy (vehicle group:90%±4%, immunized group:60%±7%/vehicle group:95%±1%, immunized group:75%±3%, P<0.05). Conclusion AT1-AA-positive rats after pregnancy showed the phenomenon of gestational hypertension, such as elevated blood pressure and impaired vascular function. These suggested that the presence of AT1-AA in healthy individuals was a risk factor for gestational hypertension.

Key words: Angiotensin Ⅱ type 1 receptor, autoantibody, blood pressure, vascular dysfunction

CLC Number:

R714.252

Bian Jingwei, Yin Xiaochen, Li Hao, Zhang Suli, Wang Meili, Liu Huirong. Angiotensin Ⅱ type 1 receptor autoantibody-positive female rats showed hypertensive disorder after pregnancy[J]. Journal of Capital Medical University, 2019, 40(2): 257-262.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2019.02.019

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I2/257

References

[1] Tranquilli A L, Dekker G, Magee L, et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy:a revised statement from the ISSHP[J]. Preg Hypertens, 2014, 4(2):97-104.
[2] Cunningham M W, Castillo J, Ibrahim T, et al. AT1-AA (angiotensin Ⅱ type 1 receptor agonistic autoantibody) blockade prevents preeclamptic symptoms in placental ischemic rats[J]. Hypertension, 2018, 71(5):886-893.
[3] Wallukat G, Homuth V, Fischer T, et al. Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor[J]. J Clin Invest, 1999, 103(7):945-952.
[4] Lei J, Li Y, Zhang S, et al. The prognostic role of angiotensin Ⅱ type 1 receptor autoantibody in non-gravid hypertension and pre-eclampsia:a meta-analysis and our studies[J]. Medicine (Baltimore), 2016, 95(17):e3494.
[5] Zhou C C, Zhang Y, Irani R A, et al. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice[J]. Nat Med, 2008, 14(8):855-862.
[6] Yang J, Li L, Shang J Y, et al. Angiotensin Ⅱ type 1 receptor autoantibody as a novel regulator of aldosterone independent of preeclampsia[J]. J Hypertension, 2015, 33(5):1046-1056.
[7] LaMarca B, Wallace K, Granger J. Role of angiotensin Ⅱ type I receptor agonistic autoantibodies (AT1-AA) in preeclampsia[J]. Curr Opin Pharmacol, 2011, 11(2):175-179.
[8] Cunningham M W, Williams J M, Amaral L, et al. Agonistic autoantibodies to the angiotensin Ⅱ type 1 receptor enhance angiotensin Ⅱ-induced renal vascular sensitivity and reduce renal function during pregnancy[J]. Hypertension, 2016, 68(5):1308-1313.
[9] Zhang S, Zheng R, Yang L, et al. Angiotensin type 1 receptor autoantibody from preeclamptic patients induces human fetoplacental vasoconstriction[J]. J Cell Physiol, 2013, 228(1):142-148.
[10] Yang X, Wang F, Chang H, et al. Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation[J]. J Hypertens, 2008, 26(8):1629-1635.
[11] Wang B, Liao Y, Zhou Z, et al. Arterial structural changes in rats immunized by AT1-receptor peptide[J]. Heart Vessels, 2005, 20(4):153-158.
[12] Parrish M R, Murphy S R, Rutland S, et al. The effect of immune factors, tumor necrosis factor-alpha, and agonistic autoantibodies to the angiotensin Ⅱ type I receptor on soluble fms-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancy[J]. Am J Hypertens, 2010, 23(8):911-916.
[13] Harmon A C, Cornelius D C, Amaral L M, et al. The role of inflammation in the pathology of preeclampsia[J]. Clin Sci (Lond), 2016, 130(6):409-419.
[14] 张真真, 戴姝艳.血管紧张素Ⅱ2型受体对大鼠子宫内膜异位症血管生成的影响[J].中国医科大学学报,2018,47(9):792-796.

[1]	Zuo Yingting, Wu Shouling, Chen Shuohua, Tian Xue, Xu Qin, Zhang Yijun, Zhang Xiaoli, Wang Anxin. Cardiovascular risk of isolated systolic or diastolic hypertension in subjects with abnormal glucose metabolism [J]. Journal of Capital Medical University, 2023, 44(1): 42-48.
[2]	Liu Xiangtong, Tao Lixin, Yang Kun, Li Haibin, Guo Jin, Guo Xiuhua. Association between hemoglobin and metabolic syndrome: a five-year follow-up [J]. Journal of Capital Medical University, 2016, 37(4): 509-512.
[3]	Wang Yunzhen, Yu Bin, Han Ruquan. Aggressive blood pressure management on regional cerebral oxygen saturation in patients undergoing carotid endarterectomy [J]. Journal of Capital Medical University, 2016, 37(4): 529-533.
[4]	Tian Junping, Wang Hong, Wang Hongxia, Zhao Xingquan, Chen Buxing. Relationship between circadian blood pressure rhythms and outcome in diabetic and nondiabetic patients with ischemic stroke [J]. Journal of Capital Medical University, 2016, 37(1): 62-69.
[5]	Ren Tianhua, Yang Tiecheng, Li Jianguo, Niu Chi, Li Lixia, Shi Hongmei. Effect of early blood pressure variability on the prognosis of patients with severe cerebral hemorrhage [J]. Journal of Capital Medical University, 2015, 36(5): 773-777.
[6]	SUN Xiuyun, WU Tao, LU Xiaoqin, CUI Shuqi, ZHANG Dongmei, SUN Zhonghua, GUO Aimin. Epidemiological tendency and influencing factors of high-normal blood pressure among rural residents in original Chongwen District, Beijing [J]. Journal of Capital Medical University, 2013, 34(1): 130-133.
[7]	WANG Yan;ZHAO Xia;FAN Bin;FENG Jian-ping;Yang Jin-kui. Effect of blood pressure control on nephropathic end-point in type 2 diabetes mellitus in an observational cohort [J]. Journal of Capital Medical University, 2012, 33(4): 472-476.
[8]	Abudoushalamu·Abudoureyimu;LIU Tao;Mierban·Abulike;Muhuyati. Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases [J]. Journal of Capital Medical University, 2012, 33(3): 399-402.
[9]	HOU Hai-xia;HUA Qi;CHEN Hui-min;LIU Rong-kun;YANG Zheng. Correlation between blood pressure variability and renal dysfunction in patients with primary hypertension [J]. Journal of Capital Medical University, 2011, 32(5): 626-628.
[10]	ZHANG Li-min;WU Qing-jun;FENG Sheng;ZENG Xiao-feng. Comparison of Five Different Disease Activity Scoring Scales for ANCAassociated Vasculitis [J]. Journal of Capital Medical University, 2010, 31(1): 103-105.
[11]	WANG Xiao-mei;ZHAO You-ping;WANG Qi;ZHANG Wei-yuan;CUI Man-hua. Clinical Significance of Ambulatory 24-hour Blood Pressure Monitoring during Middle Pregnancy [J]. Journal of Capital Medical University, 2009, 30(3): 364-367.
[12]	Liu Song;Liu Li;Zhang Ning;Li Ping;Xu Linghua;He Zhengyi. Effect of Continuous Positive Airway Pressure Treatment on the Rise of Morning Blood Pressure in the Patients with Obstructive Sleep Apnea and Hypopnea Syndrome [J]. Journal of Capital Medical University, 2008, 29(5): 632-635.
[13]	Tan Jing;Hua Qi;Liu Rongkun;Yang Zheng. Efficacy of Domestic Valsartan in the Treatment of Mild to Moderate Essential Hypertension Evaluated by Ambulatory Blood Pressure Monitoring [J]. Journal of Capital Medical University, 2008, 29(2): 209-211.
[14]	Liu Zhi;Hua Qi;Zhu Hongxu;Li Dongbao. The Characteristics of Blood Pressure Variability in Patients with Hypertension and Obstructive Sleep Apnea [J]. Journal of Capital Medical University, 2007, 28(4): 519-521.
[15]	Zhang Jianmin;Lü Hong;Liu Zhongyu;Zheng Tiehua;Wang Fang. Clinical Effect of High Epidural Anesthesia on Controlled Reduction of Blood Pressure in Infants During Operation of Patent Ductus Arteriosus Ligation [J]. Journal of Capital Medical University, 2006, 27(4): 547-549.