Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases

doi:10.3969/j.issn.1006-7795.2012.03.024

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (3): 399-402.doi: 10.3969/j.issn.1006-7795.2012.03.024

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Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases

Abudoushalamu·Abudoureyimu, LIU Tao^1,2, Mierban·Abulike², Muhuyati³

1. Graduate Student of 6th Term, Graduate College, Xinjiang Medical University,Urumqi 830000, China;2. Department of Geriatrics, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi 830000, China;3. Institute of Pediatrics, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi 830000, China;4. Department of General Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China

Received:2012-03-25 Revised:1900-01-01 Online:2012-06-21 Published:2012-06-21

Abstract

Abstract: Objective This was a prospective observational study on effects of valsartan and irbesartan in patients with diabetic nephropathy on trace urinary albumin and blood pressure.Methods A prospective observational study was conducted on 106 cases of type 2 diabetic patients with nephropathy. The patients were randomly divided into two groups (A and B), patients in group A (n = 51) were treated with valsartan 80 mg/d, those in group B (n = 55) were treated with irbesartan 150 mg/d, for 12 weeks as a course, for each course of treatment, microalbuminuria, and blood pressure were measured for a total of three courses. Results (1) Valsartan and irbesartan groups' trace urinary albumin during three courses of treatment difference had statistically significant difference (Z=-6.490 P <0.001). (2) The blood pressure of the two groups during the three courses of treatment was significantly different (P <0.05); in each course of treatment the systolic blood pressure was significantly different (P<0.05).Conclusion Both drugs could reduce microalbuminuria and had antihypertensive effect in patients with diabetic nephropathy, while irbesartan was more effective in lowering blood pressure as compared with valsartan.

Key words: valsartan capsules, irbesartan tablets, diabetic nephropathy, urinary albumin, blood pressure

CLC Number:

R 587.2

Abudoushalamu·Abudoureyimu;LIU Tao;Mierban·Abulike;Muhuyati. Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases[J]. Journal of Capital Medical University, 2012, 33(3): 399-402.

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Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases

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