Effects of tangshenning on HGF expression of renal tissue in type 2 diabetic KK-Ay mice

doi:10.3969/j.issn.1006-7795.2015.05.016

Abstract

Abstract: Objective To study the effects of Tangshenning on the protein expression of Hepatocyte Growth Factor (HGF) in KK-Ay mice with spontaneous type 2 diabetic mellitus(T2DM). Methods Diabetic male KK-Ay mice were randomly divided into three groups: the model group, the valsartan group and the Tangshenning group, with 20 in each. Twenty male C57BL/6J mice were chosen as the normal group. After intervention with Tangshenning and valsartan for 12 weeks, hemoglobin A1c (HbA1c), blood urea nitrogen (BUN)and serum creatinine (SCr) were examined. Expression of HGF was assessed by Western blotting. Results Compared with blank group, HbA1c, BUN and SCr in model group are significantly increased (P<0.05) while the expression of HGF was significantly decreased. Compared with model group, there were no significant changes in the levels of HbA1c (P>0.05). The mean levels of BUN and SCr in both treatment group were lower than model group (P<0.05). The expression of HGF was significantly increased. Conclusion Tangshenning can decrease BUN, SCr and prevent DN by promoting the expression of HGF.

Key words: diabetic nephropathy, Tangshenning, KK-Ay mice, hepatocyte growth factor(HGF)

CLC Number:

R285.5

Liu Yingxin, Zou Dawei, Geng Jianguo, Gao Yanbin, Shang Yawen, Li Jiaoyang, Gong Muxin, Peng Qizhen. Effects of tangshenning on HGF expression of renal tissue in type 2 diabetic KK-Ay mice[J]. Journal of Capital Medical University, 2015, 36(5): 747-750.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.05.016

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I5/747

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