The role and mechanism of gut microbiota in the development of diabetic nephropathy

doi:10.3969/j.issn.1006-7795.2025.04.024

Abstract

Abstract: Diabetic nephropathy (DN) ranks as a frequent and serious complication in diabetes mellitus, and it's a key factor in chronic kidney disease and end-stage renal disease(ESRD), greatly diminishing the life quality of patients. Presently, the conventional treatment approaches for DN mainly involve strict regulation of blood sugar and pressure, in conjunction with the application of renin-angiotensin-aldosterone system inhibitors. While these therapies can slow down the advancement of DN, they are ineffective in stopping its final development into ESRD. Lately, the involvement of the gut-kidney axis in the development and advancement of DN has attracted growing interest. Individuals suffering from DN show changes in the variety of gut microbiota, which are crucial in the development and management of DN due to metabolic interactions with the host. The goal of this analysis is to explore the fundamental processes of gut microbiota's role in DN and explore treatment approaches focusing on gut microbiota, aiming to offer new perspectives for the clinical handling of DN.

Key words: diabetic nephropathy, gut microbiota, gut-kidney axis, metabolites, probiotics, fecal microbiota transplantation

CLC Number:

R587.2

Han Mei, , Zhang Gang , Zhao Jin , Wang Anjing , Hui Yueqing , Sun Shiren. The role and mechanism of gut microbiota in the development of diabetic nephropathy[J]. Journal of Capital Medical University, 2025, 46(4): 742-748.

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