Abstract: Objective To investigate the treatment options for patients with non-atypical endometrial hyperplasia (EH) who present the abnormal uterine bleeding (AUB). Methods We retrospectively reviewed medical charts between June 2011 and June 2018 at a tertiary hospital and identified 394 cases of AUB with non-atypical endometrial hyperplasia. Results Totally 394 patients included 258 patients with simple EH and 136 patients with complex EH. The response of simple EH group to progesterone therapy was significantly better than that of complex EH group. The distribution of three different project of progesterone in the two groups was significantly different. The proportion of periodic progesterone in the simple EH group was significantly higher than that in the complex EH group.6 patients in the complex EH group had hysterectomy because of the progress or the persistence of the lesion,while none of the patients in the simple EH group. Hysterectomy:31 patients in the simple EH group and 35 patients in the complex EH group were treated with hysterectomy. Compared with the hysterectomy specimens,the diagnostic curettage (D&C) may be the underdiagnosis for complex EH. In the complex EH from D&C,two endometrial carcinoma and 8 cases of atypical hyperplasia were misdiagnosed. Conclusion D&C is safety and effective for most patients with EH,especially for simple EH. In clinical practice,any patients should be treated with progesterone,and the lesions should be closely monitored.

Key words: endometrial hyperplasia without atypia, atypical hyperplasia, simple endometrial hyperplasia, complex endometrial hyperplasia, diagnostic curettage