Relationship between sarcopenia and bone mineral density in middle-aged and aged men with type 2 diabetes mellitus

doi:10.3969/j.issn.1006-7795.2020.01.023

Abstract

Abstract: Objective To explore the relationship between sarcopenia and bone mineral density (BMD) in middle-aged and aged men with type 2 diabetes mellitus (T2DM). Methods All 218 men with T2DM aged over 55 years were selected from the Department of Endocrinology of Xuanwu Hospital. The BMD of lumbar spine and hip, appendicular skeletal muscle mass (ASM), appendicular fat mass (AFM), appendicular skeletal muscle mass index (ASMI), body mass index(BMI) were measured. The association between sarcopenia and osteoporosis was assessed. Results The prevalence of sarcopenia in men aged over 55 years with T2DM was 34.86%. The BMD of the participants in sarcopenia group was significantly lower than that in non-sarcopenia group. Multivariate Logistic regression analysis showed sarcopenia was an independent risk for osteoporosis in men with T2DM(OR=2.76, 95% CI: 1.20~6.34, P=0.017). Conclusion The sarcopenia is closely related to osteoporosis in middle-aged and aged men with T2DM.

Key words: sarcopenia, type 2 diabetes mellitus(T2DM), osteoporosis, muscle mass, bone mineral density

CLC Number:

R587.l

Li Yaao, Xiu Shuangling, Wang Li. Relationship between sarcopenia and bone mineral density in middle-aged and aged men with type 2 diabetes mellitus[J]. Journal of Capital Medical University, 2020, 41(1): 119-124.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.01.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I1/119

References

[1] 贾佳,孟岩,张黎黎,等.2型糖尿病患者静态平衡功能的分析[J].首都医科大学学报,2019,40(1):6-10.
[2] 罗令,孙晓峰,皮丕喆,等.近10年来我国中老年人群骨质疏松症患病率的荟萃分析[J].中国骨质疏松杂志,2018,24(11):1416-1420.
[3] Xiu S, Chhetri J K, Sun L, et al. Association of serum prealbumin with risk of osteoporosis in older adults with type 2 diabetes mellitus:a cross-sectional study[J]. Ther Adv Chronic Dis, 2019, 10:2040622319857361.
[4] Moon S S. Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population:The Korea National Health and Nutrition Examination Survey (KNHANES)2009-2010[J]. Endocr J,2014,61(1):61-70.
[5] American Diabetes Association. Executive summary:Standards of medical care in diabetes-2013[J]. Diabetes Care, 2013, 36(Supplement 1):S4-S10.
[6] Baumgartner R N. Body composition in healthy aging[J]. Ann N Y AcadSci, 2000,904(1):437-448.
[7] Baumgartner R N, Koehler K M, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico[J]. Am J Epidemiol, 1998, 147(8):755-763.
[8] Rondanelli M, Guido D, Opizzi A, et al. A path model of sarcopenia on bone mass loss in elderly subjects[J]. J Nutr Health Aging,2014,18(1):15-21.
[9] Frontera W R, Hughes V A, Fielding R A, et al. Aging of skeletal muscle:a 12-yr longitudinal study[J]. J Appl Physiol, 2000, 88(4):1321-1326.
[10] Kim T N, Park M S, Yang S J, et al. Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes:the Korean Sarcopenic Obesity Study (KSOS)[J]. Diabetes Care, 2010,33(7):1497-1499.
[11] Anbalagan U P,Venkataraman U, Pradeepa R, et al. The prevalence of presarcopenia in Asian Indian individuals with and without type 2 diabetes[J]. Diabetes Technol Ther, 2013, 15(9):768-775.
[12] Sugimoto K, Tabara Y, Ikegami H, et al. Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass:The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus[J]. J Diabetes Investig, 2019,10(6):1471-1479.
[13] Yoon J W, Jang H C.Response:hyperglycemia is associated with impaired muscle quality in older men with diabetes:the korean longitudinal study on health and aging[J]. Diabetes Metab J, 2016, 40(2):140-146.
[14] Mori H, Kuroda A, Araki M, et al. Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes[J]. J Diabetes Investig, 2017, 8(3):377-382.
[15] Tam C S, Chaudhuri R, Hutchison A T, et al. Skeletal muscle extracellular matrix remodeling after short-term overfeeding in healthy humans[J]. Metabolism, 2016, 67:26-30.
[16] Park S W, Goodpaster B H, Strotmeyer E S, et al. Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes:the health, aging, and body composition study[J]. Diabetes Care, 2007, 30(6):1507-1512.
[17] Coin A, Perissinotto E, Enzi G, et al. Predictors of low bone mineral density in the elderly:the role of dietary intake, nutritional status and sarcopenia[J]. Eur J Clin Nutr,2008,62(6):802-809.
[18] Wu C H,Yang K C, Chang H H, et al. Sarcopenia is related to increased risk for low bone mineral density[J].J ClinDensitom,2013,16(1):98-103.
[19] Pereira F B,Leite A F,de Paula A P. Relationship between pre-sarcopenia, sarcopenia and bone mineral density in elderly men[J].Arch Endocrinol Metab, 2015,59(1):59-65.
[20] Verschueren S, Gielen E, O'Neill T W, et al. Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men[J]. Osteoporos Int, 2013,24(1):87-98.
[21] Hong W, Cheng Q, Zhu X, et al. Prevalence of sarcopenia and its relationship with sites of fragility fractures in elderly Chinese Men and Women[J]. PLoS ONE, 2015, 10(9):e0138102.
[22] Perrini S, Laviola L, Carreira M C, et al. The GH/IGF1 axis and signaling pathways in the muscle and bone:mechanisms underlying age-related skeletal muscle wasting and osteoporosis[J]. J Endocrinol,2010, 205(3):201-210.
[23] Glass D J. Signaling pathways perturbing muscle mass[J]. Curr Opin Clin Nutr Metab Care, 2010, 13(3):225-229.
[24] Terracciano C, Celi M, Lecce D, et al. Differential features of muscle fiber atrophy in osteoporosis and osteoarthritis[J]. Osteoporos Int,2013, 24(3):1095-1100.
[25] 修双玲,李亚奥,李恺丽,等.老年女性2型糖尿病患者骨密度与握力的相关性研究[J].中国骨质疏松杂志,2018,24(3):332-335.
[26] Aydin G, Atalar E, Keles I, et al. Predictive value of grip strength for bone mineral density in males:site specific or systemic?[J]. Rheumatol Int, 2006, 27(2):125-129.
[27] 滑丽美,薛苏娟,曹婧然,等.中老年人维生素D水平对骨质疏松的影响及相关性分析[J].临床误诊误治,2018,31(12):76-79.