The relationship between ADIPOR1 rs7539542 and the susceptibility of coronary artery disease and type 2 diabetes in Han population

doi:10.3969/j.issn.1006-7795.2020.06.012

Abstract

Abstract: Objective To analyze whether single nucleotide polymorphisms (SNPs) in non-intronic regions contributed to coronary artery disease (CAD) or type 2 diabetes (T2D) risk. Methods Seven hundred thirty-seven subjects who had undergone coronary arteriography were included in this multi-disease comparative study, with gender-, age-, and body mass index-matched among groups. There were 193 controls, 142 patients with T2D, 203 with CAD, and 199 with T2D and CAD. Three SNPs (rs7539542 G>C and rs10581 C>T at 3′ untranslated regions (UTR), rs7517286 T>C at 5′UTR) were genotyped by direct Sanger sequencing. Results rs7539542 C allele was positively associated with both CAD (OR=1.67-2.34, P=2.87×10^-4-0.002) and CAD with T2D (OR=1.52-2.08, P=0.003-0.016). Further analysis of case-case comparative results showed that rs7539542 C allele was associated with an increased risk of CAD in T2D patients (OR=1.58-2.90, P=0.002-0.038). Subgroup analyses of blood pressure level suggested that the above associations could only be found in the non-hypertension subgroup. For gene-environment interactions in the non-hypertension subgroup, rs7539542 CC genotype correlated with triglyceride level and contributed to a higher risk of CAD (OR=5.006, P=0.041) and CAD with T2D (OR=5.381, P=0.04). No significant association was found between rs7517286 or rs10581 variant and CAD or T2D(P＞0.05). Conclusion Our results suggest that rs7539542 at 3′UTR of ADIPOR1 is associated with CAD independently, especially in non-hypertension subjects.

Key words: adiponectin receptor 1, rs7539542, coronary artery disease, type 2 diabetes, association

CLC Number:

R541
R587

Li Xiang, Pu Lianmei, Ruan Yang, Li Hong, Jin Zening. The relationship between ADIPOR1 rs7539542 and the susceptibility of coronary artery disease and type 2 diabetes in Han population[J]. Journal of Capital Medical University, 2020, 41(6): 935-942.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.06.012

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I6/935

References

[1] Yanai H, Yoshida H. Beneficial effects of adiponectin on glucose and lipid metabolism and atherosclerotic progression: mechanisms and perspectives[J]. Int J Mol Sci,2019,20(5):1190.
[2] Patel S A, Hoehn K L, Lawrence R T, et al. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity[J]. Endocrinology,2012,153(11):5231-5246.
[3] Luo N, Chung B H, Wang X, et al. Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages[J]. Atherosclerosis,2013,228(1):124-135.
[4] Yamauchi T, Nio Y, Maki T, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions[J]. Nat Med,2007,13(3):332-339.
[5] Wang M, Wang D, Zhang Y, et al. Adiponectin increases macrophages cholesterol efflux and suppresses foam cell formation in patients with type 2 diabetes mellitus[J]. Atherosclerosis,2013,229(1):62-70.
[6] Stern M P. Diabetes and cardiovascular disease. The “common soil” hypothesis[J]. Diabetes,1995,44(4):369-374.
[7] Wang F, Suo S, Sun L, et al. Analysis of the relationship between adipor1 variants and the susceptibility of chronic metabolic diseases in a Northeast Han Chinese population[J]. Genet Test Mol Biomarkers,2016,20(2):81-85.
[8] Jin Z, Pu L, Sun L, et al. Identification of susceptibility variants in ADIPOR1 gene associated with type 2 diabetes, coronary artery disease and the comorbidity of type 2 diabetes and coronary artery disease[J]. PLoS One,2014,9(6):e100339.
[9] Li H, Yang Z, Pu L M, et al. Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes[J]. J Geriatr Cardiol,2016,13(9):776-782.
[10]Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension[J]. J Hypertens,2018,36(10):1953-2041.
[11]Soccio T, Zhang Y Y, Bacci S, et al. Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes[J]. Diabetes,2006,55(10):2763-2770.
[12]Qi L, Doria A, Giorgi E, et al. Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis[J]. Diabetes,2007,56(6):1586-1591.
[13]Yeh E, Kimura L, Errera F I, et al. Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry[J]. Braz J Med Biol Res,2008,41(6):468-472.
[14]Collins S C, Luan J, Thompson A J, et al. Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations[J]. Diabetologia,2007,50(3):555-562.
[15]Vaxillaire M, Dechaume A, Vasseur-Delannoy V, et al. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population[J]. Diabetes,2006,55(3):856-861.
[16]Hara K, Horikoshi M, Kitazato H, et al. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes[J]. Diabetologia,2005,48(7):1307-1314.
[17]Kim J T, Kim Y, Cho Y M, et al. Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans[J]. Clin Endocrinol (Oxf),2009,70(1):66-74.
[18]Mora-Garcia G, Ruiz-Diaz M S, Espitia-Almeida F, et al. Variations in ADIPOR1 but not ADIPOR2 are associated with hypertriglyceridemia and diabetes in an admixed latin American population[J]. Rev Diabet Stud,2017,14(2-3):311-328.