Analysis of clinical characteristics of patients with duodenal papilla neoplasms and the diagnostic value for advanced carcinoma

doi:10.3969/j.issn.1006-7795.2023.06.014

Abstract

Abstract: Objective To explore valuable indicators for the differential diagnosis of early and advanced duodenal papilla neoplasms (DPNs).Methods Data of general conditions, laboratory tests and imaging examinations including digestive endoscopy were collected from patients with DPNs. LASSO (least absolute shrinkage and selection operator) regression was used to screen predictive factors. Univariate and multivariate Logistic analysis were used to determine the independent risk factors for advanced DPNs. ResultsA total of 95 DPNs patients were included in this study. Symptoms, carbohydrate antigen 125 （CA125）, CA50, γ-glutamyltransferase （GGT), total bilirubin （TBIL） and hemoglobin （Hb) were screened out by LASSO regression for Logistic regression analysis. Finally, clinical symptoms, elevated GGT and CA50 were validated to be independent predictors of progressive DPNs (P<0.05). Conclusion The clinical symptoms such as jaundice, significantly increased GGT and CA50 are independent risk factors, and it may be more valuable than imaging examination in the judgment of DPNs as advanced carcinoma.

Key words: duodenal papilla neoplasms, biomarker of tumor, advanced stage carcinoma, early-stage carcinoma

CLC Number:

R574

Qiao Xinwei, Qiu Yuting, Li Peng, Wu Jing, Zhang Shutian. Analysis of clinical characteristics of patients with duodenal papilla neoplasms and the diagnostic value for advanced carcinoma[J]. Journal of Capital Medical University, 2023, 44(6): 990-998.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.06.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I6/990

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