Abstract: Objective To evaluate the safety of pancreatic duct stent placement through duodenal accessory papilla cannulation. Methods Data of 114 patients with pancreatic diseases who underwent duodenal papilla cannulation and pancreatic stent placement in Beijing Friendship Hospital from January 2016 to August 2021 were analyzed retrospectively. There were 88 patients underwent the main papilla cannulation,while 26 patients treated by accessory papilla cannulation.We compare the differences of the age, sex, previous history, history of endoscopic retrograde cholangiopancreatography (ERCP) operation, operator, preoperative blood coagulation function, endoscopic pancreatic sphincterotomy, difficult cannulation, number of pancreatic duct stents, post-ERCP complications, the length of hospital stay after ERCP between two groups.The independent risk factors for postoperative complications were analyzed by binary Logistic regression.Results There was no significant difference in the incidence of postoperative complications and length of hospital stay after ERCP between the two groups (P>0.05), and binary Logistic regression showed that duodenal accessory papilla cannulation was not a risk factor for post-ERCP complications(P>0.05). Conclusion According to the current limited data, the placement of pancreatic duct stent through duodenal accessory papilla cannulation will not increase the incidence of the incidence of post-ERCP complications and the length of hospital stay compared with main papilla cannulation.

Key words: duodenal accessory papilla, pancreatic duct stent, endoscopic retrograde cholangiopancreatography