Cerebral angiographic features and prognostic study in patients with central retinal artery occlusion

doi:10.3969/j.issn.1006-7795.2025.01.004

Abstract

Abstract: Objective To analyze the cerebral angiographic characteristics of patients with central retinal artery occlusion (CRAO) and to study their prognosis. Methods A retrospective study was conducted, with 182 CRAO patients enrolled, who were treated at Xuanwu Hospital, Capital Medical University, the First Affiliated Hospital of Anhui Medical University, the Affiliated Suzhou Hospital of Anhui Medical University, and the People's Hospital of Shihezi City from January 1, 2014, to June 1, 2024. All patients underwent cerebral angiography within one month of onset. The baseline characteristics, treatment details, and follow-up data were collected. The Spearman rank correlation coefficient was used to evaluate the correlation between the characteristics of the ophthalmic artery and the ipsilateral carotid artery angiography, and Logistic regression analysis was performed to explore factors related to patient prognosis. Results Cerebral angiography results showed that 81.3% of patients had ocular blood supply from the ipsilateral internal carotid artery, 12.1% from the ipsilateral external carotid artery, and 6.6% from the ipsilateral middle cerebral artery. Among the patients, 80 (44.0%) had varying degrees of stenosis or occlusion of the affected ophthalmic artery, with 69 patients (86.3%) showing stenosis at the origin of the ophthalmic artery. Additionally, 135 patients (74.2%) had varying degrees of stenosis or occlusion of the ipsilateral carotid artery, with 110 patients (60.4%) showing stenosis at the carotid bulb, 88 patients (48.3%) having unilateral carotid lesions, and 41 patients (22.5%) having multiple lesions. Correlation analysis indicated a significant correlation between the degree of stenosis in the ophthalmic artery and the carotid artery (r =0.76, P =0.006). Univariate and multivariate Logistic regression analyses revealed that the time from symptom onset to hospital admission (OR=0.93, 95% CI: 0.85 － 0.98, P=0.018), the grading of oxygenation-based hypoperfusion maculopathy (OHM) (OR=3.12, 95% CI: 1.09 － 6.34, P=0.005), intravenous thrombolysis (IVT) (OR=2.75, 95% CI: 1.08 － 5.35, P=0.031), and the absence of stenosis in the ophthalmic artery (OR=1.33, 95% CI: 1.02 － 3.41, P=0.026) were independent predictors of prognosis for CRAO patients. Conclusions The degree of stenosis in the ophthalmic artery is significantly correlated with the degree of stenosis in the carotid artery in CRAO patients. Time from symptom onset to hospital admission, OHM grading, IVT, and the absence of stenosis in the ophthalmic artery are independent factors influencing the prognosis of CRAO patients.

Key words: central retinal artery occlusion, cerebral angiography, prognosis

CLC Number:

R743

Ya• Naren, Liu Yan, Zhou Xia, Zhu Dekun, Chen Feng, Ma Zhengfei, Li Chuanhui, Sun Zhongwu. Cerebral angiographic features and prognostic study in patients with central retinal artery occlusion[J]. Journal of Capital Medical University, 2025, 46(1): 15-21.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2025.01.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2025/V46/I1/15

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