Abstract: To evaluate effect of Sandostatin in prevention and treatment of stress ulceration for acute severe brain injury patients, 30 patients with acute severe brain injury (GCS 3～8) were admitted into this study. Besides neurosurgery routine treatments, they received sandostatin during the first 7 days (0.1 mg, per 8 h) and were observed in the next 3 weeks. The other 86 patients with acute severe brain injury, as the controls, just received histamine H 2 antagonist treatment. Only 4 (13.3%) of the 30 patients in sandostatin group suffered from upper gastrointestinal hemorrhage, and all happened in the first 24 h and were controlled within 1 d. In the control group, 16 patients (18.6%) suffered from upper gastrointestinal hemorrhage(P<0.05). Conclusion: sandostatin is effective for prevention and treatment of the stress ulceration in acute sever brain injury patients.

Key words: sandostatin, acute severe brain injury, stress ulceration