Abstract: The rat model of cerebral post-ischemia reperfusion was employed in the experiment to explore whether the values of indicator of blood viscosity and erythrocyte deformation had significant difference between the experimental groups and the control group. It was found that the blood viscosity declined during ischemia, mainly because of the compensation of RBC. During reperfusion viscosity of both blood and serum increased, but there was a tendency for viscosity to return to the normal level at the point of 12 h after onset of reperfusion. These results indicate that the reduction of ATP and the release of some chemical factors during ischemia induced the change. Long time reperfusion can compensate for it. With the increase of shear rate, the erythrocyte deformation increased exponentially and the math equation of this model was set up at the same shear rate: φ= a+b×e^[-c(x-x₀)]. It was found that erythrocyte deformation varied greatly. This is not only related to its ischemia and acidosis, but the biological character of RBC is involved.

Key words: post-ischmia reperfusion, hemorheology, RBC deformation, blood viscosity, shear rate