Abstract: To analyses of the relations between the changes in ultra microstructure of hippocampus amygdala and the temporal lobe epilepsy, the normal preoperational examinations of EEG, V-EEG and MRI were performed in 35 patients with temporal lobe epilepsy. The abnormal hippocampus and amygdala were resected with the intraoperative deep brain monitoring of EEG and the ultra structure examination were performed. Changes of different degrees were observed in ultra microstructure of neurons in epileptic areas. The neuro fiber was slackened and stuck together. The number of excitatory transmitters in presynaptic terminals of axospinal asymmetric synapses was increased. Rough surfaced endoplasmic reticulum(RER)was expland. Astrocytes were swollen mildly. There were more stricking changes in microstructure of all 35 cases which were observed and the changes were unifformed. The pathologic changes of the neuro in the foci play a more important role in the mechanism of the formation and the development of temporal lobe epilepsy.

Key words: temporal lobe epilepsy, hippocampus-amygdala, ultra-microstructure