Abstract: This study explored the pathogenesis of myasthenia gravis(MG)complicated wity epilepsy. The study analyzed the clinical manifestation and experimental results of 15 MG patients complicated wity epilepsy. The attack of epilepsy occurred with the aggravation of the clinical symptom of MG and relived with the improvement of MG respectively. The levels of CSF IgG and the CSF IgG 24 h synthetic rate in the group with MG complicated with epilepsy(MG+EPI)were higher than those in the other two groups, the group of MG without EPI(MG-EPI)and the control group. The attack of epilepsy is related with the abnormally synthetic acetylcholine receptor antibody(AchRab)in the central nervous system.

Key words: myasthenia gravis, epilepsy, pathogenesis