Detection and Significance of c-myc Protein in Invasive Breast Carcinoma

Journal of Capital Medical University ›› 2002, Vol. 23 ›› Issue (2): 135-138.

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Detection and Significance of c-myc Protein in Invasive Breast Carcinoma

Zhang Dong¹, Gao Dongchen¹, Zhang Changhuai², Lu Xiaomei², Chen Shuyuan²

1. Department of General Surgery, Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Pathology, Beijing Friendship Hospital, Affiliate of Capital University of Medical Sciences

Received:2001-12-07 Revised:1900-01-01 Online:2002-04-15 Published:2002-04-15

Abstract

Abstract: To investigate the clinical significance of c-myc protein expression in breast cancer, the expression of c-myc protein in 116 breast cancer tissues was examined using immunohistochemical methods(SP). Nuclear expression of c-myc protein was detected in 11.2% of tumors, and it was related to prognosis. Cytoplasmic expression of c-myc protein was present in 93.1% of the carcinomas. Moderate to strong c-myc protein expression in cytoplasmic was associated with the positive status of ER. The result shows that nuclear expression of c-myc protein appears to be an important prognostic factor. To investigate the expression of c-myc protein in breast cancer may to some extent act as guidance to the therapy of breast carcinomas.

Key words: breast cancer|c-myc|immunohistochemical methods

CLC Number:

R737.9

Zhang Dong;Gao Dongchen;Zhang Changhuai;Lu Xiaomei;Chen Shuyuan. Detection and Significance of c-myc Protein in Invasive Breast Carcinoma[J]. Journal of Capital Medical University, 2002, 23(2): 135-138.

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Detection and Significance of c-myc Protein in Invasive Breast Carcinoma

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