Abstract: The objective is to study the effects of 11,12-epoxyeicosatrienoic acid(11,12-EET)on the cardio pulmonary cerebral resuscitation(CPCR). Using the classical method to reproduce the resuscital model, we bring the CPCR into effect at the moment when the heartbeat stopped. Then we observed the succeed rate of resuscitation, the resume rate and time of independent circle and the change of the left heart function. Preconditioning with 11,12-EET or applying 11,12-EET in CPCR can enhance the success rate of CPCR, shorten the resume time of independent circle and improve the heart function after CPCR. The study indicates that 11,12-EET can improve the prognosis of CPCR.

Key words: 12-epoxyeicosatrienoic acid|cardio pulmonary cerebral resuscitation|ischemia/reperfusion