Journal of Capital Medical University ›› 2002, Vol. 23 ›› Issue (4): 323-325.

• 临床研究 • Previous Articles     Next Articles

Analysis of Polymorphism in Exon 7 of Human Cytochrome P4501A1 Gene in Chinese

Zhang Liqun1, Chu Jinhua2, Zhou Yan3, Zhu Zhangling3, Deng Yifu 2   

  1. 1. Respiratory Department of Beijing Military District General Hospital;2. Department of Preventive Medicine, Capital University of Medical Sciences;3. Basic Medicine Research Centre, Beijing Chaqang Hospital, Affiliate of Capital University of Medical Sciences
  • Received:2001-10-18 Revised:1900-01-01 Online:2002-10-15 Published:2002-10-15

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Abstract: P4501A1 is a kind of enzyme related with the carcinogenic activity of aromatic hydrocarbon, the polymorphism in exons 7 of the gene could alter the function, and has been reported to be associated with lung cancer in Japanese. But data from Caucasian or African-American were different. The difference is said to be from the different frequencies of this polymorphism between ethnic groups. This paper analyzed the frequency of polymorphism in exons 7 of CYP1A1 gene in Chinese by the PCR method. The results suggested that the frequencies of genotype in Chinese were Ile/Ile 61.6%, Ile/Val 26.4% and Val/Val 12.0%, no significant difference of the frequencies between male and female was found. But the frequency of Val/Val was much higher than that in Japanese, Caucasian or African American.

Key words: CYP1A1|polymorphism|Chinese

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