Abstract: The objective was to observe and analyze the clinical features and related factors in SARS(severe acute respiratory syndrome)patients in severe condition.Methods:Clinical data of 149 patients with probable SARS in severe condition admitted in Xuanwu Hospital were analyzed retrospectively,including general appearance,clinical manifestations,laboratory findings,radiological findings,ECG,treatment and outcome respectively.Result:In 149 SARS patients in severe condition aged from 25to 75,the following were symploms:accompanied chronic diseases(40.3%),fever(96.0%),normal or decreased blood white cell count(58.0%),lymphopenia(78.7%),increased serum enzymes(60%),decreased albumin/globulin ratio(46.9%),increased glucose(37.6%),hypooxygenemia(53.1%),larger lung tissue damage site(81.8%),ECG abnormality(31.7%),complications(58.7%).Treatment included corticosteriods,antifungals,antibacterials and antivirals,immunopotentiator,traditional Chinese medicine,oxygen supply and mechanically supported respiration.The final recovery(87.2%)and mortality(12.8%)were found in these patients.Conclusion:Senility,underlying diseases,complications and larger lung tissue damag,severe abnormality in serum enzyme examination contribute to severe condition and higher mortality in SARS patient.

Key words: SARS, severe condition, clinical features