Abstract:

Objective The purpose of study was to explore the effects of different plasma insulin levels on systolic blood pressure of rat model. Methods Experimental animals were divided into three groups randomly: insulin osmotic mini-pump group (induced-hyperinsulinemia); alloxan-induced diabetes group (induced-hypoinsulinemia & hyperglycemia) and normal control group (normal insulinemia). Hyperinsulinemia animal model was induced by injection of insulin subcutaneously through of a mini-pump, hypoinsulinemia and hyperglycemia animal models were induced by intraperitoneal injection of alloxan (40 mg/kg), and then the plasma insulin and glucose levels were measured on the experimental day of 0, 2, 5, 8, 11, 15, respectively, the systolic blood pressure was measured on the experimental day of 1, 4, 7, 10, 13, 16, respectively. Results The insulin osmotic mini-pump induced significant hyperinsulinemia compared with control group(P<0.05), and the significant systolic blood pressure uprising was observed on the experimental day of 10, untie the end of the experiment in the insulin osmotic mini-pump group.There was a significant difference between hyperisulinemia group and the others(P<0.01), otherwise, there was no obviously systolic blood pressure increasing in both control group and alloxan group, although the systolic blood pressure of alloxan group to be observed an increasing trend on the experimental day of 13 and 16, respectively, but there was no significant statistic meaning compared with control group(P>0.05). Conclusion Exogenous insulin can induce uprising of systolic blood pressure of rats; there is no significant variations of systolic blood pressure in model of hypoinsulinemia and hyperglycemia during the experimental period.

Key words: hyperinsulinemia, hypoinsulinemia, hyperglycemia, systolic blood pressure