Abstract: Objective To investigate the profile of anesthesia with midazolam and propofol.Methods 90 patients were randomly allocated into three groups. In group A, patients were induced with midazolam 0.2 mg·kg^-1 and maintained with 0.15 mg·kg^-1 ·h^-1. In group B, propofol 1～2 mg·kg^-1 was used for induction, and 2～4 mg·kg^-1 ·h^-1 for maintenance. In group C, midazolam 0.1 mg·kg^-1 and propofol 0.5¹ mg·kg^-1 were used for induction, and midazolam 0.1 mg·kg^-1 ·h^-1 and propofol 1～2 mg·kg^-1 ·h^-1 were infused for maintenance. Fentanyl 1～3 μg·kg^-1 and vecuronium were injected intravenously and 1%～1.5% isoflurane was inhaled as needed. SBP, DBP, HR and SpO₂ were monitored continuously during anesthesia. The recovery was observed.Results SBP, DBP, HR, SpO₂ of every stage were compared with those of preanesthesia in each group, it was found that SBP, DBP in group C had no difference (P>0.05), and had significant difference in group A and B (P<0.05). The patients awakened (34.44±12.35) min after operation with 6 anxiety, 11 nausea, 9 vomiting and no case dream during the first 24 h after surgery in group A, The patients awakened fast (6.56±5.74) min with 9 anxiety, 7 dream, 13 nausea, 11 vomiting and 16 pain during the first 24 h after the operations in group B, The patients opened their eyes (14.64±9.50) min after surgery with 5 anxiety, 2 dream, 8 nausea, 4 vomiting and 10 pain during the first 24 h after operations in group C.Conclusion The combination of midazolam and propofol is a suitable method for general anesthesia.

Key words: midazolam, propofol, general anesthesia