Abstract: Psoriasis is a chronic inflammatory disease.The etiology is involved in many factors including genetic predisposition and environmental impact.The heritability degree of psoriasis is estimated between 60% and 80%.Many investigators pay attention to the genetic predisposition and epidemiologic feature and begin to study the correlation between chromosome aberration or gene mutation and pathogenesis.More and more clinical case reports and laboratory studies about psoriasis associated with acute myelogenous leukemia have been reported.Most of the patients with psoriasis and leukemia are the subtype of AML-M3.Someone consider the psoriasis with leukemia is caused by bimolane.On the other hand,the others consider there are some genetic defects existed in the patients with psoriasis,including chromosome instability and defect of DNA repair.Here is the review about the relationship between psoriasis and leukemia.