Abstract: Objective In order to assess the diagnostic value of BNP for high blood-volume and cardiac function,we detect the changes of plasma brain natriuretic peptide(BNP) in patients with predialysis chronic kidney diseases(CKD).Methods Plasma BNP concentrations were measured in 152 CKD patients and 32 healthy control subjects.The CKD patients were divided into four groups according to the glomerular filtration rate(GFR) by Cockcroft's formula:CKD-Ⅰ and Ⅱ;CKD-Ⅲ,CKD-Ⅳ,and CKD-Ⅴ groups.Echocardiographic examinations were performed to determine the cardiac structure and function.The inferior vena caval diameter were measured.Results Median plasma BNP concentrations increased with declining estimated GFR in CKD Groups(P<0.05);Spearman correlation showed that the BNP level was positively correlated with LVDd,LVDs and the width of postcava,but negatively correlated with LVEF.Conclusion BNP is a sensitive marker for monitoring the condition of cardiac function in CKD patients.

Key words: brain natriuretic peptide, chronic kidney diseases, liquid overload, chronic heart failure