Abstract:

The discovery of lead compounds is a key step to drug design. Pseudopeptide is one of the most important lead structures. Various pseudopeptides could be prepared based on either the structures or the mechanisms of action. For the design of the anti-thrombotic, thrombolytic, anti-tumor, anti-osteoporosis and lead detoxification drugs, in the past years we published numerous reports on pseudopeptides of alkaloid-peptides, heterocyclics-peptides, steroid-peptides, saccharide-amino acids and so on. This paper reviews the pharmacological benefits of some pseudopeptides of our laboratory.

Key words: pseudopeptide, drug design, anti-thrombotic, thrombolytic, anti-tumor, anti-osteoporosis, lead detoxification