Abstract: Objective To establish an esophageal cancer high incidence screening area in Wu'an City, Hebei Province, a pilot study was carried out before largescale endoscopic screening. Methods Home by home survey was launched in Shangtuancheng village, Shangtuancheng Town, Wu'an city, and 40~65 year-old residents were registered to conduct a questionnaire survey. After obtaining informed consent, endoscopy for esophageal cancer and precancerous lesions was performed. Results Among 92 residents who had been surveyed, 88 accepted endoscopy, 19 residents were suspected of having esophageal cancer and precancerous lesions were biopsied, and sent to department of pathology; 7 cases of low or moderate dysplasia, 2 cases of high-grade dysplasia/carcinoma in situ, and 1 case of advanced esophageal cancer were confirmed pathologically.Conclusion This study confirmed the feasibility of esophageal cancer screening in high incidence area, which helps accumulate experience for the future long-term research.

Key words: esophageal cancer, precancerous lesions, gastroscopy endoscopy, high incidence area