Abstract: Objective To investigate the changes in blood lipid, serum uric acid, fibrinogen, platelet level in patients with cerebral infarction and myocardial infarction. Methods A total of 206 patients were divided into 3 groups: myocardial infarction group(n=69), cerebral infarction group(n=72), cerebral infarction complicated with myocardial infarction group(n=65), and 76 healthy persons were enrolled into control group. Triglyceride(TG), total cholesterol(TCH), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C ), apolipoprotein A1 (Apo-A1), apolipoprotein B(ApoB), serum uric acid(UA), fibrinogen(Fib), plateletcrit(PCT), mean platelet volume(MPV) and platelet volume distribution width(PDW) were examined for all subjects. ResultsIn cerebral infarction group and myocardial infarction group, the UA, Fib level was higher than that of control group(P<0.01, P<0.05); the MPV, LDL-C level was higher than that of control group(P<0.05), and cerebral infarction and myocardial infarction had no interactive effect on the changes of UA, Fib, MPV, and LDL-C. The PDW level in cerebral infarction group and myocardial infarction group was higher than that of control group, PCT level was lower than that of control group(P<0.05); TG, TCH and APOB were higher than those of control group(P<0.05); HDL and APOA1 level were lower than that of control group(P<0.01). Cerebral infarction and myocardial infarction had interactive effects on the changes in PDW and PCT(P<0.01) and on TG, TCH, APOB, APOA1, and HDL-C(P<0.05). Conclusion Monitoring of blood lipid, serum uric acid, fibrinogen, and platelet levels is helpful in diagnosis and predicting the prognosis in patients with cerebral infarction and myocardial infarction.

Key words: cerebral infarction, myocardial infarction, blood lipid, serum uric acid, fibrinogen, platelet