Levels of sRAGE and IFN-γ in the plasma of patients with acute coronary syndrome and their relationship with the severity of coronary artery lesions

doi:10.3969/j.issn.1006-7795.2023.02.014

Abstract

Abstract: Objective To investigate the plasma levels of soluble receptor for advanced glycation end product (sRAGE) and interferon-γ (IFN-γ) in patients with different types of acute coronary syndromes and their relationship with the severity of coronary artery lesions. Methods A total of 236 patients who underwent coronary angiography in Beijing Tiantan Hospital, Capital Medical University from June 2016 to June 2018 were included and divided into acute myocardial infarction group (n=42), unstable angina pectoris group (n=119), non-(coronary heart disease, CHD) group (n=75). The levels of sRAGE and IFN-γ in the plasma of each group were detected and compared by enzyme-linked immunosorbent assay. The differences of sRAGE and IFN-γ in patients with acute myocardial infarction and unstable angina pectoris in different Gensini score groups and their correlation with the number of coronary artery lesions were analyzed， respectively. The correlations between sRAGE and IFN-γ and myocardial infarction markers cardiac troponin I (cTnI), myoglobin (Myo) and creatine kinase isoenzyme (CK-MB) in patients with acute myocardial infarction were analyzed. Results The sRAGE level was the highest in the acute myocardial infarction group and the lowest in the non-coronary heart disease group. The level of IFN-γ in the acute myocardial infarction group was higher than that in the unstable angina pectoris group and the non-coronary heart disease group, and there was no significant difference between the unstable angina pectoris group and the non-coronary heart disease group. Multivariate Logistic regression analysis showed that elevated sRAGE level was an independent risk factor for acute myocardial infarction and unstable angina, and was more closely related to acute myocardial infarction. In patients with acute myocardial infarction, sRAGE and IFN-γ were positively correlated, and both were positively correlated with myocardial infarction markers cTnI, Myo, and CK-MB, but had no significant correlation with Gensini score and the number of coronary artery lesions. In unstable angina pectoris, the levels of sRAGE and IFN-γ in the high GS group were higher than those in the medium Gensini group and the low Gensini group. The sRAGE level was the highest in the three-vessel disease group and the lowest in the single-vessel disease group, and the IFN-γ level was the highest in the double-vessel disease group and the lowest in the single-vessel disease group. Conclusion The level of sRAGE in the plasma of patients with acute coronary syndrome is significantly increased, and the level of sRAGE in patients with acute myocardial infarction is higher than that in patients with unstable angina pectoris. The levels of sRAGE and IFN-γ in unstable angina pectoris were positively correlated with the severity of coronary artery disease.

Key words: acute coronary syndrome, acute myocardial infarction, unstable angina pectoris, soluble receptor for advanced glycation end-products (sRAGE), γ-interferon (IFN-γ)

CLC Number:

R541

Luo Xiaomeng, Jiang Xue, Du Fenghe, Guo Caixia. Levels of sRAGE and IFN-γ in the plasma of patients with acute coronary syndrome and their relationship with the severity of coronary artery lesions[J]. Journal of Capital Medical University, 2023, 44(2): 272-279.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.02.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I2/272

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