Correlation between serum calcium and cardiovascular outcome in patients with acute coronary syndrome

doi:10.3969/j.issn.1006-7795.2023.01.023

Abstract

Abstract: Objective To investigate the relationship between serum calcium and cardiovascular prognosis in patients with acute coronary syndrome (ACS). Method A total of 721 ACS patients hospitalized in the Department of Cardiovascular Medicine, Beijing Tiantan Hospital,Capital Medical University from June 2019 to December 2019 were selected, and all patients underwent coronary angiography. The clinical data of the patients were collected and blood samples were drawn to determine biochemical indexes such as serum calcium. All patients were followed up for 1 year. And the occurrence of endpoint events was recorded. The relationship between serum calcium and cardiovascular prognosis in ACS patients was analyzed. Results Among the 721 ACS patients, the mean age was (62.23±10.00) years, 527 (73.1%) were males, and the mean follow-up was (10.92±2.96) months. Among them, 110 patients (15.26%) had an end point event, including 1 case of cardiovascular death, 3 cases of recurrent myocardial infarction, 103 cases of unstable angina, and 3 cases of ischemic stroke. All patients were divided into group Q₁ (<2.20 mmol/L), group Q₂ (2.20－2.26 mmol/L), group Q₃ (2.27－2.31 mmol/L) and group Q₄ (≥2.32 mmol/L).The proportion of patients with acute myocardial infarction in Q1 group was higher than that in Q₃ and Q₄ groups (P <0.05), the GRACE score in Q₁group was higher than that in Q₂, Q₃and Q₄ groups (P<0.05), and the incidence of cardiovascular events in Q₁ group was higher than that in Q₄ group (P<0.05). Kaplan-meier analysis showed that patients with the lowest serum calcium level had a worse cardiovascular prognosis (log-rank χ²=9.787, P=0.020). In addition, after adjusting for potential confounders in the multivariate Cox proportional risk model, lower serum calcium level (HR=0.096, 95%CI:0.014－0.646, P=0.016) was independently associated with cardiovascular outcomes. Conclusion Low serum calcium level is an independent risk factor for adverse cardiovascular outcome in patients with ACS. And the decrease of serum calcium level has an important reference value for identifying high-risk ACS patients.

Key words: acute coronary syndrome, serum calcium, Global Registry of Acute Coronary Events, prognosis

CLC Number:

R541.4

Wang Rongrong, Tian Junping. Correlation between serum calcium and cardiovascular outcome in patients with acute coronary syndrome[J]. Journal of Capital Medical University, 2023, 44(1): 154-160.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.01.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I1/154

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