Abstract: The assay was to study whether the hepatic lesion would exist in patients with gallbladder stone without the typical symtoms. The biopsy of liver tissue was simultaneously performed, when the cholecystectomy was undergone for 100 patients with gallbladder stone.Only 3 cases whose duration of illness were less than 3 months had not abnormality, the remaining 97 cases all existed various kind of the lesions. Because the hepatocyte lesion existed in patients with gallstone,if the diagnosis of gallbladder stone was determined, the cholecystectomy should be needed.

Key words: the recessive cholelithiasis, lesion of liver, cholecystectomy