Abstract: To raise the accuracy of clinical diagnose on chronic hepatitis B, the correlation between the clinical features, biochemical tests 〔the serum total bilirubin-TBil, albumin(ALB), prothrobin activity(PTA), alanine aminotransferase(ALT), albumin/globulin(A/G), γ-globulin(γ-G)〕 and histopathological data of 202 patients with chronic hepatitis B(CHB)were studied. The Resultes were that some of presenting symptoms and signs were obviously associated with histological grade and stage. The grade of necroinflammatory activity of CHB is associated with the rising of TBIL, ALT, γ-G and the declining of A/G and PTA. The coincidence of clinical diagnose and pathology for ΑLB and γ-G might reach 92.7%, 90.2% in mild chronic hepatitis; the coincidence was lower in moderate chronic hepatitis;the coincidence for PTA,TLB, TBil were 41.0%,38.5%,25.6% in marked chronic hepatitis. However, if the biochemical tests were syntheticlly judged, the coincidence might reach 95.9%, 77.5%, 74.4% in mild, moderate and marked chronic hepatitis. The conclusion might be drawn that great attention should be paid to the significance of symptoms and signs, meanwhile a synthetic judgment biochemical testes is necessary for the diagnosis of CHB.

Key words: hepatitis B, clinic, pathology