Detection and significance of anti-C1q antibody in the diagnosis of children with systematic lupus erythematosus

doi:10.3969/j.issn.1006-7795.2014.06.024

Abstract

Abstract:

Objective The aim of this study was to determine the associations of anti-C1q antibody with patients of children with systemic lupas erythematosus(SLE) and its potential clinica1 significance,and to explore its early clinical diagnostic significance for children with systemic lupas erythematosus. Methods There are 40 cases of SLE and 20 healthy volunteers in children were derived from the First Affiliated Hospital of Baotou Medical College from Jun.2009 to Dec.2013, the laboratory data of 40 cases of SLE were retrospectively analyzed,such as anti-SSA, anti-SSB, anti-RNP, anti-dsDNA, anti-SM, C3, C4. A method of enzyme-linked immunosorbent assay was used to detect the serum anti-C1q antibodies in 40 cases of SLE and 20 healthy volunteers, and the correlation between the anti-C1q antibodies and the laboratory data was analyzed. Results 1) The mean age was similar in children with systematic lupus erythematosus and controls(P>0.05). 2) Among 40 SLE children, the anti-C1q antibodies of 15 SLE children were positive, while the anti-C1q antibodies of 20 healthy controls were negative. Significant difference between the two groups(χ²=8.1, P<0.01).The sensitivity of anti-C1q antibodies in SLE children was 37.5% and the specificity was 100%. The sensitivity for anti-dsDNA antibodies was 62.5% and the specificity was 95%. The sensitivity for anti-SM antibodies was 22.5% and the specificity was 90%. 3) Comparing anti-C1q-positive and -negative patients, there was no difference in concentrations of anti-SSA, anti-SSB, anti-RNP, anti-Sm, C3, C4. However, there are significant differences between the two groups of anti-dsDNA antibodies(χ²=5.98, P=0.02). 4) A positive correlation was found between anti-dsDNA levels and both anti-C1q(r=0.51, P<0.01). Conclusion Our study demonstrated ClqAb has a higher sensitivity in diagnosis of SLE in children, which is helpful to the diagnosis of SLE in children with negative anti-dsDNA antibodies.

Key words: children systematic lupus erythematosus, anti-C1q antibodies, anti-dsDNA antibodies

CLC Number:

R816.92

Yin Fangrui, Pang Chunyan, Bai Li, Wang Xin, Wang Yongfu. Detection and significance of anti-C1q antibody in the diagnosis of children with systematic lupus erythematosus[J]. Journal of Capital Medical University, 2014, 35(6): 809-812.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.06.024

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I6/809

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