Abstract: Objective To investigate the macular disorders by optical coherence tomography(OCT) in patients and residents of Changping District, Beijing, and to analyze the type and risk factors of macular diseases. Methods In a cross-sectional population-based study, OCT was performed for subjects from the 2011 Health Examination Survey in Beijing. The subjects also received physical examination and laboratory measurements including fasting plasma glucose(FPG), oral glucose tolerance test(OGTT)-2 h plasma glucose(2 h PG), hemoglobin A1C(HbA1c), uric acid and lipid profiles, in addition to completing a general health questionnaire. Results The study included 521 subjects who had at least one eye meeting study eligibility criteria. Of all subjects, two patients had age-related macular degeneration(AMD), five patients had diffuse macular edema without cysts, six patients had cystoid macular edema, three patients had tractional macular edema, two patients had serious retinal detachments. More importantly, FPG(P=0.024), OGTT-2 h PG(P=0.029), total cholesterol(P=0.024) and low-density lipoprotein(LDL)(P=0.044) cholesterol were found to be the independent risk factors for macular disease. Central subfield thickness(CST) of the retina was significantly greater in patients with macular disease than in normal controls(P < 0.001). Conclusion Patients with macular disease had greater central subfield thickness. FPG, 2 h PG, total cholesterol and LDL-C were found to be the independent risk factors for macular disease.

Key words: fasting plasma glucose, macular disease, optical coherence tomography