Study of ApoEε4 gene combined with sMRI in mild cognitive impairment

doi:10.3969/j.issn.1006-7795.2017.01.012

Journal of Capital Medical University ›› 2017, Vol. 38 ›› Issue (1): 59-62.doi: 10.3969/j.issn.1006-7795.2017.01.012

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Study of ApoEε4 gene combined with sMRI in mild cognitive impairment

Ma Jun^1,2, Wang Zhaohui³, Gu Xuesong¹, Man Fengyuan⁴

1. Department of Radiology, Hospital of Beihua University, Jilin 132011, Jilin Province, China;
2. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;
3. Department of Neurology, Hospital of Beihua University, Jilin 132011, Jilin Province, China;
4. Department of Radiology, The General Hospital of the PLA Rocket Force, Beijing 100088, China

Received:2016-11-28 Online:2017-01-21 Published:2017-01-20
Supported by:
This study was supported by Jilin Provincial Department of Education Funding[2011] 144.

Abstract

Abstract: Objective To evaluate demographics, neuropsychological performance, structural magnetic resonance imaging (sMRI) measures, and apolipoprotein E genotype among four mild cognitive impairment (MCI) subtypes. Methods A total of 94 subjects with MCI and 53 cognitively normal older participants (controls) were evaluated. Classification of subjects with MCI into four subtypes based on neuropsychological performance, were investigated about sMRI research and ApoEε4 genotype. Medial temporal lobe atrophy (MTA) and prevalence of white matter hyperintensity (WMH) were assessed by sMRI. In addition, to study the relationship between Minimum Mental State Examination (MMSE) score, MTA score and ApoEε4 score, WMH and MCI subtypes. Results Severity of MMSE and MTA differed among MCI subtypes and control group. We found that 2 amnestic forms of MCI patients had significantly higher MTA scores than the 2 nonamnestic forms of MCI patients. However, there are not significant differences in WMH among the MCI subtypes. Apolipoprotein E genotype prevalence was significantly higher in the amnestic compared with nonamnestic subtypes of MCI. In addition, in amnestic MCI-single domain (aMCI-SD) and amnestic MCI-multiple domain (aMCI-MD) subjects, presence of ApoEε4 allele had a significant impact on the severity of MTA and memory deficits. Conclusion The different subtypes of MCI, may display biological heterogeneity, suggesting that sMRI in combination with the ApoEε4 genotype might be more helpful to predict progression from MCI to dementia.

Key words: mild cognitive impairment, clinical subtypes, structural magnetic resonance imaging, medial temporal lobe atrophy, apolipoprotein Eε4 genotype, white matter hyperintensity

CLC Number:

R741

Ma Jun, Wang Zhaohui, Gu Xuesong, Man Fengyuan. Study of ApoEε4 gene combined with sMRI in mild cognitive impairment[J]. Journal of Capital Medical University, 2017, 38(1): 59-62.

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Study of ApoEε4 gene combined with sMRI in mild cognitive impairment

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