Rapeutic effect of azelastine nasal spray combined with desloratadine in the treatment of allergic rhinitis: a system review and Meta-analysis

doi:10.3969/j.issn.1006-7795.2018.03.027

Abstract

Abstract: Objective To analyze therapeutic effect of azelastine nasal spray combined with desloratadine in the treatment of allergic rhinitis by Meta analysis.Methods Retrieved database:Chinese database includes CNKI, Wan Fang, VIP, CBM, etc. The English database includes PubMed, Embase, MEDLINE, Cochrane and so on. The quality evaluation was made by the Newcastle Ottawa Scale (NOS). Useing RevMan5.3 software to process data. The statistical effect index was selected by risk ratio (RR) value and 95%CI, I² and P values were selected as indicators of heterogeneity test, and sensitivity analysis, subgroup analysis were carried out. And conduct publication bias assessment. Publication bias was assessed by the Egger's method, if necessary further analysis will be made. Result Compared with azelastine nasal spray combined with desloratadine group and azelastine nasal spray group in the treatment of allergic rhinitis, Z=8.18(P<0.000 01), RR(95% CI):1.21(1.16,1.27) and the difference was statistically significant (P<0.05). Subgroup analysis showed that A group Z=5.62(P<0.000 01) and RR(95% CI):1.18(1.12, 1.26), and the difference was statistically significant (P<0.05). B Group Z=3.62(P=0.000 3) and RR(95% CI):1.19 (1.08, 1.31), the difference was statistically significant (P<0.05). C group Z=4.91(P<0.000 01), RR(95% CI):1.33(1.19, 1.50), the difference was statistically significant (P<0.05). Sensitivity analysis showed that Z=6.27(P<0.000 01), RR(95% CI):1.19(1.13, 1.26), the difference was still statistically significant (P<0.05).Conclusion Azelastine nasal spray combined with desloratadine is better than Azelastine nasal spray in the treatment of allergic rhinitis.

Key words: azelastine nasal spray, desloratadine, allergic rhinitis, Meta-analysis

CLC Number:

R765.21

Gao Zhanmei, Song Yang, Liu Hua, Wen Changlong, Sun Haiyang. Rapeutic effect of azelastine nasal spray combined with desloratadine in the treatment of allergic rhinitis: a system review and Meta-analysis[J]. Journal of Capital Medical University, 2018, 39(3): 458-464.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.03.027

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I3/458

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