Abstract: Objective To test the expression of brain-specific angiogenesis inhibitor-1 (BAI-1) in cervical lesion, and analyze the significance in the development of cervical squamous cell carcinomas and the correlation with human papillomavirus (HPV) infection. Methods By SP method and PCR reverse dot hybridization to summarize and analyze the expression of BAI-1 and infection of HPV in 30 cases of normal cervical tissue, 61 cases of cervical intraepithelial neoplasia (CIN) (CIN Ⅰ 27 cases, CIN Ⅱ-Ⅲ 34 cases) and 54 cases of cervical squamous carcinoma tissues (Ⅰ-Ⅱ 34 cases, Ⅲ-IV 20 cases), discussing the correlation in the development of cervical squamous cell carcinoma and the correlation with HPV infection. Results The positive expression rates of BAI-1 in normal cervical tissue, CIN Ⅰ, CIN Ⅱ -Ⅲ and cervical squamous cell carcinoma tissues were 96.67%, 74.07%, 44.11% and 18.52%. And the positive infection rates of HPV were 6.67%, 37.04%, 76.47% and 100%. By analyzing the data, as the cervical lesions progressed, the positive expression rate of BAI-1 was falling gradually, and the positive infection rate of HPV was rising gradually, differences between groups were statistically significant (P<0.01). The positive expression of BAI-1 was only relevant with the clinical stage (χ²=7.219, P=0.007), and has nothing to do with age, histological grade and lymph node metastasis; the positive expression of BAI-1 was negatively correlated with the positive infection rate of HPV (r_s=-0.486, P<0.01) in different cervical tissues. Conclusion BAI-1 was may participate in the early lesion process of cervical cancer of HPV infection, to provide a new direction for diagnosis, treatment and prognosis of cervical squamous carcinoma.

Key words: brain-specific angiogenesis inhibitor-1, human papillomavirus infection, cervical squamous cell carcinomas