Correlation between metabolic characteristics of ocular adnexal lymphoma manifested by 18F-FDG PET/CT and its clinical stage

doi:10.3969/j.issn.1006-7795.2021.01.004

Abstract

Abstract: Objective To analyze the relationship between the metabolic parameters of ocular adnexal lymphoma (OAL) by ¹⁸F-fluorodeoxyglucose(¹⁸F-FDG) positron emission tomography/computed tomography(PET/CT) and its clinical stage, and compare the differences of metabolic parameters between different pathological types of OAL.Methods A total of 37 patients who underwent ¹⁸F-FDG PET/CT in the Department of Nuclear Medicine of the First Medical Center of PLA General Hospital from April 2012 to April 2020 and was diagnosed as OAL by pathology were enrolled. The maximum standardized uptake value (SUVmax), average standardized uptake value (SUVmean), metabolic tumor volume (MTV) and total lesion glycolysis lesion (TLG) were retrospectively analyzed, respectively. Ann Arbor classification was based on PET/CT results and clinical data. The patients were grouped according to main pathological types, and the differences in the metabolic parameters between the groups were compared to each other to explore the correlations between the metabolic parameters and different stages. Results The pathological classification was mainly B-cell lymphoma in the extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT, n=13), diffuse large B-cell lymphoma (DLBCL, n=12) and extranodal natural killer/T-cell lymphoma, nasal type (ENK-TCL, n=7). By comparing the metabolic parameters of the above three groups, the differences of metabolic parameters between DLBCL, ENK-TCL and MALT were statistically significant (P<0.01). In all 37 patients, there were significant differences in SUVmax and TLG among different stages (P<0.05), and the metabolic parameters were positively correlated with disease stages, and the correlation between TLG and MTV were stronger than that between SUVmax and SUVmean. Conclusion The metabolic parameters manifested by ¹⁸F-FDG PET/CT were correlated with clinical stage, especially TLG and MTV.

Key words: ocular adnexal lymphoma, positron emission tomography/computed tomography(PET/CT), metabolic parameters, diagnosis, staging

CLC Number:

Wang Guanyun, Yang Hui, Chen Jiaxin, Xiao Wentian, Li Can, Yao Shulin, Wang Ruimin, Xu Baixuan. Correlation between metabolic characteristics of ocular adnexal lymphoma manifested by ¹⁸F-FDG PET/CT and its clinical stage[J]. Journal of Capital Medical University, 2021, 42(1): 21-25.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.01.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I1/21

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Correlation between metabolic characteristics of ocular adnexal lymphoma manifested by ¹⁸F-FDG PET/CT and its clinical stage

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