Abstract: Objective To identify the risk factors associated with bleeding events after ultrasound-guided percutaneous native renal biopsies. Methods Research subjects were 1 026 admitted patients who underwent renal biopsy in the second affiliated Hospital of Xi'an Jiaotong University from January 2019 to December 2021. We compared means of clinical indicators between bleeding patients (343 cases) and non-bleeding (683 cases) patients. Correlations were analyzed between bleeding size and each clinical indicator in all patients or bleeding patients. We selected the influence factors associated with bleeding events by Logistic regression. Results There were 343 (33.4%) cases with bleeding which were detected by ultrasound, including 5 cases (0.49%) with major bleeding which received therapy. The bleeding rate in women after renal biopsy was significantly higher than that in men (37.8% vs 29.4%, P<0.05). Among all the basic information and clinical indicators, body mass index, hemoglobin, red blood cells, platelets, urine specific gravity, urine protein, triglyceride, total cholesterol, prothrombin activity, thrombin time in bleeding group were all significantly lower than non-bleeding group. Oppositely, prothrombin time, international normalized ratio in bleeding group were all significantly higher than non-bleeding group. By further analyzing the data of the bleeding group, we found that the size of the hematoma was significantly positively correlated with fasting blood glucose and activated partial thromboplastin time. Through multivariate Logistic regression analysis, platelet counts were identified as high risk factors for bleeding events (OR=0.996, P<0.05). Conclusion Lower platelets counts are the high risk factors associated with bleeding events after ultrasound-guided percutaneous native renal biopsies.

Key words: renal biopsy, bleeding events, high risk factors